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Central serotonin receptors as targets for drug research Richard A. Glennon pp 1 - 12; DOI: 10.1021/jm00384a001 |
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1-2-(Pyridinyl)piperazine derivatives with antianaphylactic, antibronchospastic and mast cell stabilizing activities Alberto Catto, Gianni Motta, Alberto Tajana, Pietro Cazzulani, Dante Nardi, and Amedeo Leonardi pp 13 - 19; DOI: 10.1021/jm00384a002 |
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Synthesis and biological properties of side-chain-modified bleomycins Wilhelmus J. Vloon, Cornelis Kruk, Upendra K. Pandit, Hendricus P. Hofs, and John G. McVie pp 20 - 24; DOI: 10.1021/jm00384a003 |
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Synthesis and antisecretory and antiulcer activities of derivatives and analogs of 2-(2-pyridyl)tetrahydrothiophene-2-carbothioamide Jean-Claude Aloup, Jean Bouchaudon, Daniel Farge, Claude James, Jean Deregnaucourt, and Monique Hardy-Houis pp 24 - 29; DOI: 10.1021/jm00384a004 |
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Phenylpiperazine-based radiopharmaceuticals for brain imaging. 3. Synthesis and evaluation of radioiodinated 1-alkyl-4-phenylpiperazines Robert N. Hanson and Mohammad Hassan pp 29 - 34; DOI: 10.1021/jm00384a005 |
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Dopamine agonists related to 3-allyl-6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol, 6-position modifications Stephen T. Ross, Robert G. Franz, Gregory Gallagher, Martin Brenner, James W. Wilson, Robert M. DeMarinis, J. Paul Hieble, and Henry M. Sarau pp 35 - 40; DOI: 10.1021/jm00384a006 |
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Synthetic analogs of tetrahydrobiopterin with cofactor activity for aromatic amino acid hydroxylases E. C. Bigham, G. K. Smith, J. F. Reinhard, W. R. Mallory, C. A. Nichol, and R. W. Morrison pp 40 - 45; DOI: 10.1021/jm00384a007 |
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Cluster significance analysis contrasted with three other quantitative structure-activity relationship methods James W. McFarland and Daniel J. Gans pp 46 - 49; DOI: 10.1021/jm00384a008 |
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2,4-Diamino-6,7-dimethoxyquinazolines. 1. 2-[4-(1,4-Benzodioxan-2-ylcarbonyl)piperazin-1-yl] derivatives as .alpha.1-adrenoceptor antagonists and antihypertensive agents Simon F. Campbell, Michael J. Davey, J. David Hardstone, Brian N. Lewis, and Michael J. Palmer pp 49 - 57; DOI: 10.1021/jm00384a009 |
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Antiradiation compounds. 20. 1-Methylquinolinium(and pyridinium)-2-dithioacetic acid derivatives William O. Foye, Robert W. Jones, Pallab K. Ghoshal, and Bijan Almassian pp 57 - 62; DOI: 10.1021/jm00384a010 |
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Synthesis and antilipolytic activities of quinolyl carbanilates and related analogs John H. Musser, Utpal Chakraborty, Kevin Bailey, Stan Sciortino, Carol Whyzmuzis, Dilip Amin, and Charles A. Sutherland pp 62 - 67; DOI: 10.1021/jm00384a011 |
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(5Z)-7-(2,2-Dimethyl-4-phenyl-1,3-dioxan-cis-5-yl)heptenoic acid: a specific thromboxane A2 receptor antagonist Andrew G. Brewster, Peter W. R. Caulkett, and Reg Jessup pp 67 - 70; DOI: 10.1021/jm00384a012 |
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Analogs of the cytostatic and antimitogenic agents chlamydocin and HC-toxin: synthesis and biological activity of chloromethyl ketone and diazomethyl ketone-functionalized cyclic tetrapeptides Richard E. Shute, Brian Dunlap, and Daniel H. Rich pp 71 - 78; DOI: 10.1021/jm00384a013 |
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Polychlorinated biphenyls and related compound interactions with specific binding sites for thyroxine in rat liver nuclear extracts J. McKinney, R Fannin, S. Jordan, K. Chae, U. Rickenbacher, and L. Pedersen pp 79 - 86; DOI: 10.1021/jm00384a014 |
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5-Fluoro- and 8-fluorotrimetoquinol: selective .beta.2-adrenoceptor agonists Michael T. Clark, Adeboye Adejare, Gamal Shams, Dennis R. Feller, and Duane D. Miller pp 86 - 90; DOI: 10.1021/jm00384a015 |
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Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidin-7-ones as adenosine receptor antagonists Harriet W. Hamilton, Daniel F. Ortwine, Donald F. Worth, and James A. Bristol pp 91 - 96; DOI: 10.1021/jm00384a016 |
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Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists John H. Musser, Utpal R. Chakraborty, Stanley Sciortino, Robert J. Gordon, Atul Khandwala, Edward S. Neiss, Thaddeus P. Pruss, Richard Van Inwegen, Ira Weinryb, and Stephen M. Coutts pp 96 - 104; DOI: 10.1021/jm00384a017 |
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Synthesis of N-(3,6-dihydro-1(2H)-pyridinyl)benzamides with hyperglycemic-hypoglycemic activity Jupita M. Yeung and Edward E. Knaus pp 104 - 108; DOI: 10.1021/jm00384a018 |
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Synthesis, cell-growth inhibition, and antitumor screening of 2-(p-n-butylanilino)purines and their nucleoside analogs George E. Wright, Lech W. Dudycz, Zygmunt Kazimierczuk, Neal C. Brown, and Naseema N. Khan pp 109 - 116; DOI: 10.1021/jm00384a019 |
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Synthesis and antitumor activity of tropolone derivatives. 4 Masatoshi Yamato, Kuniko Hashigaki, Junko Sakai, Youko Kawasaki, Shigeru Tsukagoshi, and Tazuko Tashiro pp 117 - 120; DOI: 10.1021/jm00384a020 |
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Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias H. D. Hollis Showalter, Judith L. Johnson, Jeanne M. Hoftiezer, William R. Turner, Leslie M. Werbel, Wilbur R. Leopold, Joan L. Shillis, Robert C. Jackson, and Edward F. Elslager pp 121 - 131; DOI: 10.1021/jm00384a021 |
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2-Phenylindoles. Effect of N-benzylation on estrogen receptor affinity, estrogenic properties, and mammary tumor inhibiting activity Erwin Von Angerer and Josef Strohmeier pp 131 - 136; DOI: 10.1021/jm00384a022 |
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Structure-activity relationships of kadsurenone analogues Mitree M. Ponpipom, Robert L. Bugianesi, David R. Brooker, Bao-zhen Yue, San-bao Hwang, and Tsung-ying Shen pp 136 - 142; DOI: 10.1021/jm00384a023 |
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Indolizidine and quinolizidine derivatives of the dopamine autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) Klaus P. Boegesoe, Joern Arnt, Max Lundmark, and Staffan Sundell pp 142 - 150; DOI: 10.1021/jm00384a024 |
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Structural alterations that differentially affect the mutagenic and antitrichomonal activities of 5-nitroimidazoles John S. Walsh, Regina Wang, Edward Bagan, C. C. Wang, Peter Wislocki, and Gerald T. Miwa pp 150 - 156; DOI: 10.1021/jm00384a025 |
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Preparation, receptor binding, and fluorescence properties of hexestrol-fluorophore conjugates: evaluation of site of attachment, fluorophore structure, and fluorophore-ligand spacing Thomas L. Fevig, John E. Lloyd, Jeffery A. Zablocki, and John A. Katzenellenbogen pp 156 - 165; DOI: 10.1021/jm00384a026 |
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Double-headed haptens with pyrocatechol (poison ivy-like) and methylene lactone functional groups: a search for skin-tolerance inducers Henri Mattes and Claude Benezra pp 165 - 168; DOI: 10.1021/jm00384a027 |
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Preparation and antitumor activity of new mitomycin A analogs Salah M. Sami, Bhashyam S. Iyengar, William A. Remers, and William T. Bradner pp 168 - 173; DOI: 10.1021/jm00384a028 |
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Substituted (aryloxy)alkanoic acids as antagonists of slow-reacting substance of anaphylaxis Ronald A. LeMahieu, Mathew Carson, Ru-Jen Han, William C. Nason, Margaret O'Donnell, Deborah L. Brown, Herman J. Crowley, and Ann F. Welton pp 173 - 178; DOI: 10.1021/jm00384a029 |
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Conformationally defined adrenergic agents. 4. 1-(Aminomethyl)phthalans: synthesis and pharmacological consequences of the phthalan ring oxygen atom John F. DeBernardis, David L. Arendsen, John J. Kyncl, and Daniel J. Kerkman pp 178 - 184; DOI: 10.1021/jm00384a030 |
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N-(heterocyclic alkyl)pyrido[2,1-b]quinazoline-8-carboxamides as orally active antiallergy agents Jefferson W. Tilley, Paul Levitan, Joan Lind, Ann F. Welton, Herman J. Crowley, Lawrence D. Tobias, and Margaret O'Donnell pp 185 - 193; DOI: 10.1021/jm00384a031 |
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Synthesis and gastrointestinal pharmacology of a 3E,5Z diene analog of misoprostol Paul W. Collins, Steven W. Kramer, Alan F. Gasiecki, Richard M. Weier, Peter H. Jones, Gary W. Gullikson, Robert G. Bianchi, and Raymond F. Bauer pp 193 - 197; DOI: 10.1021/jm00384a032 |
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Synthesis and biological evaluation of acyclic neplanocin analogs Mei Hua, Phillip M. Korkowski, and Robert Vince pp 198 - 200; DOI: 10.1021/jm00384a033 |
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Differential blockade of muscarinic receptor subtypes by polymethylene tetraamines. Novel class of selective antagonists of cardiac M-2 muscarinic receptors Carlo Melchiorre, Anna Cassinelli, and Wilma Quaglia pp 201 - 204; DOI: 10.1021/jm00384a034 |
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Substituted 2-(2-hydroxyphenyl)benzimidazoles as potential agents for the control of periodontal diseases Robert A. Coburn, Michael T. Clark, Richard T. Evans, and Robert J. Genco pp 205 - 208; DOI: 10.1021/jm00384a035 |
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Studies on the active molecular species of the H2-receptor antagonists cimetidine and mifentidine E. E. J. Haaksma, B. Rademaker, K. Kramer, J. C. Eriks, A. Bast, and H. Timmerman pp 208 - 211; DOI: 10.1021/jm00384a036 |
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Xanthine functionalized congeners as potent ligands at A2-adenosine receptors Kenneth A. Jacobson, Dieter Ukena, William Padgett, John W. Daly, and Kenneth L. Kirk pp 211 - 214; DOI: 10.1021/jm00384a037 |
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Dopamine agonists: effects of charged and uncharged analogs of dopamine Yu-An Chang, Jeffrey Ares, Karen Anderson, Brian Sabol, Raye Ann Wallace, Tahira Farooqui, Norman Uretsky, and Duane D. Miller pp 214 - 218; DOI: 10.1021/jm00384a038 |
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Differential effects of N-terminal modifications on the biological potencies of growth hormone releasing factor analogs with varying chain lengths David H. Coy, William A. Murphy, Valentine A. Lance, and Mark L. Heiman pp 219 - 222; DOI: 10.1021/jm00384a039 |
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3-[(2-Ethoxyphenoxy)methyl]piperidine derivatives. Synthesis and antidepressant activity A. Balsamo, I. Giorgi, A. Lapucci, A. Lucacchini, B. Macchia, F. Macchia, C. Martini, and A. Rossi pp 222 - 225; DOI: 10.1021/jm00384a040 |
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Nucleosides. 139. Synthesis and anticytomegalovirus and antiherpes simplex virus activity of 5'-modified analogs of 2'-fluoroarabinosylpyrimidine nucleosides Kazuho Harada, Jasenka Matulic-Adamic, Richard W. Price, Raymond F. Schinazi, Kyoichi A. Watanabe, and Jack J. Fox pp 226 - 229; DOI: 10.1021/jm00384a041 |
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Book Reviews pp 230 - 230; DOI: 10.1021/jm00384a600 |
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In search of the digitalis replacement Paul W. Erhardt pp 231 - 237; DOI: 10.1021/jm00385a001 |
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Bimorphinans as highly selective, potent .kappa. opioid receptor antagonists P. S. Portoghese, A. W. Lipkowski, and A. E. Takemori pp 238 - 239; DOI: 10.1021/jm00385a002 |
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Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of .gamma.-aminobutyric acid acting as selective GABA-A antagonists Camille Georges Wermuth, Jean Jacques Bourguignon, Gilbert Schlewer, Jean Pierre Gies, Angele Schoenfelder, Anita Melikian, Marie Jeanne Bouchet, Dominique Chantreux, Jean Charles Molimard, and et al. pp 239 - 249; DOI: 10.1021/jm00385a003 |
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Stereochemical studies on the cytochrome P-450 catalyzed oxidation of (S)-nicotine to the (S)-nicotine .DELTA.1'(5')-iminium species Lisa A. Peterson, Anthony Trevor, and Neal Castagnoli pp 249 - 254; DOI: 10.1021/jm00385a004 |
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Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogs Fortuna Haviv, James D. Ratajczyk, Robert W. DeNet, Yvonne C. Martin, Richard D. Dyer, and George W. Carter pp 254 - 263; DOI: 10.1021/jm00385a005 |
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1-[[[5-(Substituted phenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinediones, a new class of skeletal muscle relaxants R. L. White, F. L. Wessels, T. J. Schwan, and K. O. Ellis pp 263 - 266; DOI: 10.1021/jm00385a006 |
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Synthesis and evaluation of mono-, di-, and trifluoroethenyl-GABA derivatives as GABA-T inhibitors Michael Kolb, Jacqueline Barth, Jean Georges Heydt, and Michel J. Jung pp 267 - 272; DOI: 10.1021/jm00385a007 |
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Molecular modification of anticholinergics as probes for muscarinic receptors. 1. Amino esters of .alpha.-substituted phenylacetic acid and related analogs Matthias C. Lu, Walley E. Wung, Lisa B. Shih, Soledad Callejas, James E. Gearien, and Emmanuel B. Thompson pp 273 - 278; DOI: 10.1021/jm00385a008 |
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Molecular modification of anticholinergics as probes for muscarinic receptors. 3. Conformationally restricted analogs of benactyzine Michael T. Flavin, Matthias C. Lu, Emmanual B. Thompson, and Hemendra N. Bhargava pp 278 - 285; DOI: 10.1021/jm00385a009 |
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Inhibition of aspartic proteinases by peptides containing lysine and ornithine side-chain analogs of statine Francesco G. Salituro, Nirankar Agarwal, Theo Hofmann, and Daniel H. Rich pp 286 - 295; DOI: 10.1021/jm00385a010 |
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Inhibitors of cyclic AMP phosphodiesterase. 1. Analogs of cilostamide and anagrelide Gordon H. Jones, Michael C. Venuti, Robert Alvarez, John J. Bruno, Andrew H. Berks, and Anthony Prince pp 295 - 303; DOI: 10.1021/jm00385a011 |
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Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)oxy]butyramide (RS-82856) Michael C. Venuti, Gordon H. Jones, Robert Alvarez, and John J. Bruno pp 303 - 318; DOI: 10.1021/jm00385a012 |
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1-Aryl-2-(aminomethyl)cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants Bernard Bonnaud, Henri Cousse, Gilbert Mouzin, Mike Briley, Antoine Stenger, Francois Fauran, and Jean Pierre Couzinier pp 318 - 325; DOI: 10.1021/jm00385a013 |
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Structure-activity relationships of sparsomycin and its analogs. Inhibition of peptide bond formation in cell-free systems and of L1210 and bacterial cell growth Leon A. G. M. Van den Broek, Rob M. J. Liskamp, J. Hans Colstee, Peter Lelieveld, Miguel Remacha, David Vazquez, Juan P. G. Ballesta, and Harry C. J. Ottenheijm pp 325 - 333; DOI: 10.1021/jm00385a014 |
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Comparison of aminoglycoside antibiotics with respect to uptake and lethal activity in Escherichia coli Norris E. Allen, William E. Alborn, Herbert A. Kirst, and John E. Toth pp 333 - 340; DOI: 10.1021/jm00385a015 |
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Synthesis and antitumor activity of fluorine-substituted 4-amino-2(1H)-pyridinones and their nucleosides. 3-Deazacytosines Dennis J. McNamara and P. Dan Cook pp 340 - 347; DOI: 10.1021/jm00385a016 |
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2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes Barbara Roth, Barbara S. Rauckman, Robert Ferone, David P. Baccanari, John N. Champness, and Richard M. Hyde pp 348 - 356; DOI: 10.1021/jm00385a017 |
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Antitumor imidazotetrazines. 14. Synthesis and antitumor activity of 6- and 8-substituted imidazo[5,1-d]-1,2,3,5-tetrazinones and 8-substituted pyrazolo[5,1-d]-1,2,3,5-tetrazinones Edward Lunt, Christopher G. Newton, Christopher Smith, Graham P. Stevens, Malcolm F. G. Stevens, Colin G. Straw, Roger J. A. Walsh, Peter J. Warren, Christian Fizames, and et al. pp 357 - 366; DOI: 10.1021/jm00385a018 |
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NMR spectroscopic studies of intermediary metabolites of cyclophosphamide. 2. Direct observation, characterization, and reactivity studies of iminocyclophosphamide and related species Victoria L. Boyd, Michael F. Summers, Susan Marie Ludeman, William Egan, Gerald Zon, and Judith B. Regan pp 366 - 374; DOI: 10.1021/jm00385a019 |
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Synthetic and enzyme inhibition studies of pepstatin analogs containing hydroxyethylene and ketomethylene dipeptide isosteres Mark W. Holladay, Francesco G. Salituro, and Daniel H. Rich pp 374 - 383; DOI: 10.1021/jm00385a020 |
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Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl)phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating Guy D. Diana, Richard C. Oglesby, Vahan Akullian, Philip M. Carabateas, David Cutcliffe, John P. Mallamo, Michael J. Otto, Mark A. McKinlay, Edward G. Maliski, and Stephen J. Michalec pp 383 - 388; DOI: 10.1021/jm00385a021 |
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Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents Ivo Jirkovsky, George Santroch, Reinhardt Baudy, and George Oshiro pp 388 - 394; DOI: 10.1021/jm00385a022 |
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Activation mechanisms of mafosfamide and the role of thiols in cyclophosphamide metabolism Chul Hoon Kwon, Richard F. Borch, Jurgen Engel, and Ulf Niemeyer pp 395 - 399; DOI: 10.1021/jm00385a023 |
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Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters John H. Musser, Dennis M. Kubrak, Joseph Chang, Stephen M. DiZio, Mark Hite, James M. Hand, and Alan J. Lewis pp 400 - 405; DOI: 10.1021/jm00385a024 |
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Chemical differentiating agents. Differentiation of HL-60 cells by hexamethylenebis[acetamide]analogs Alberto Haces, Theodore R. Breitman, and John S. Driscoll pp 405 - 409; DOI: 10.1021/jm00385a025 |
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5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies Laman A. Al-Razzak, Douglas Schwepler, Charles J. Decedue, Jan Balzarini, Erik De Clercq, and Mathias P. Mertes pp 409 - 419; DOI: 10.1021/jm00385a026 |
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The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles Gian Luigi Biagi, Giorgio Cantelli-Forti, Anna Maria Barbaro, Maria Clelia Guerra, Patrizia Hrelia, and Pier Andrea Borea pp 420 - 423; DOI: 10.1021/jm00385a027 |
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Molecular modification of anticholinergics as probes for muscarinic receptors. 2. Amino esters of .alpha.-methyltropic acid Matthias C. Lu, Lisa B. Shih, Hwan S. Jae, James E. Gearien, and Emmanual B. Thompson pp 424 - 427; DOI: 10.1021/jm00385a028 |
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The mechanism of activation of 4-hydroxycyclophosphamide Richard F. Borch and Jo Ann Millard pp 427 - 431; DOI: 10.1021/jm00385a029 |
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5-Amino-4-(diazoacetyl)-1-.beta.-D-ribofuranosylimidazole, a new antileukemic agent H. Jeanette Thomas, Lisa N. Avery, R. Wallace Brockman, and John A. Montgomery pp 431 - 434; DOI: 10.1021/jm00385a030 |
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Prostaglandin-H synthase inhibition by malonamides. Ring-opened analogs of phenylbutazone Jonathan L. Vennerstrom and Thomas J. Holmes pp 434 - 437; DOI: 10.1021/jm00385a031 |
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Synthesis and biological properties of 9-(trans-4-hydroxy-2-buten-1-yl)adenine and guanine: open-chain analogs of neplanocin A Shashikant Phadtare and Jiri Zemlicka pp 437 - 440; DOI: 10.1021/jm00385a032 |
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Synthesis and antiviral activity of various 3'-azido, 3'-amino, 2',3'-unsaturated, and 2',3'-dideoxy analogs of pyrimidine deoxyribonucleosides against retroviruses Tai Shun Lin, Ming S. Chen, Colin McLaren, You Song Gao, Ismail Ghazzouli, and William H. Prusoff pp 440 - 444; DOI: 10.1021/jm00385a033 |
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Synthetic bovine prothrombin precursor 13-29 for studies of vitamin K dependent carboxylase Richard S. Pottorf, Daniel H. Rich, Jean Engelke, and John W. Suttie pp 445 - 448; DOI: 10.1021/jm00385a034 |
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Book Reviews Lemont B. Kier, and Lowell H. Hall pp 448 - 450; DOI: 10.1021/jm00385a600 |
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Esters of N,N-disubstituted 2-hydroxyacetamides as a novel highly biolabile prodrug type for carboxylic acid agents Hans Bundgaard and Niels Mork Nielsen pp 451 - 454; DOI: 10.1021/jm00386a001 |
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A new thienylpyrazoloquinoline: a potent and orally active inverse agonist to benzodiazepine receptors Susumu Takada, Hiroshisa Shindo, Takashi Sasatani, Akira Matsushita, Masami Eigyo, Kazuo Kawasaki, and Shunji Murata pp 454 - 455; DOI: 10.1021/jm00386a002 |
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Synthesis of 7,12-dihydropyrido[3,4-b:5,4-b']diindoles. A novel class of rigid, planar benzodiazepine receptor ligands Mark L. Trudell, Anthony S. Basile, Harlan E. Shannon, Phil Skolnick, and James M. Cook pp 456 - 458; DOI: 10.1021/jm00386a003 |
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Quantitative structure-activity analysis in dihydropteroate synthase inhibition of sulfones. Comparison with sulfanilamides Pier G. De Benedetti, Dario Iarossi, Cristina Menziani, Valeria Caiolfa, Chiara Frassineti, and Carlo Cennamo pp 459 - 464; DOI: 10.1021/jm00386a004 |
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Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3 dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids Violetta Cecchetti, Arnaldo Fravolini, Renata Fringuelli, Giuseppe Mascellani, Piergiuseppe Pagella, Maurizio Palmioli, Giorgio Segre, and Patrizia Terni pp 465 - 473; DOI: 10.1021/jm00386a005 |
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Redox chemistry of the 9-anilinoacridine class of antitumor agents Jeffrey L. Jurlina, Andrew Lindsay, John E. Packer, Bruce C. Baguley, and William A. Denny pp 473 - 480; DOI: 10.1021/jm00386a006 |
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Nucleic acid related compounds. 51. Synthesis and biological properties of sugar-modified analogs of the nucleoside antibiotics tubercidin, toyocamycin, sangivamycin, and formycin Erik De Clercq, Jan Balzarini, Danuta Madej, Fritz Hansske, and Morris J. Robins pp 481 - 486; DOI: 10.1021/jm00386a007 |
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Multisubstrate inhibitors of dopamine .beta.-hydroxylase. 2. Structure-activity relationships at the phenethylamine binding site Lawrence I. Kruse, Carl Kaiser, Walter E. DeWolf Jr., James S. Frazee, Stephen T. Ross, Joyce Wawro, Merrie Wise, Kathryn E. Flaim, John L. Sawyer, and et al. pp 486 - 494; DOI: 10.1021/jm00386a008 |
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Dopamine autoreceptor agonists: resolution and pharmacological activity of 2,6-diaminotetrahydrobenzothiazole and an aminothiazole analog of apomorphine Claus S. Schneider and Joachim Mierau pp 494 - 498; DOI: 10.1021/jm00386a009 |
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Amnesia-reversal activity of a series of cyclic imides Donald E. Butler, James D. Leonard, Bradley W. Caprathe, Yvon J. L'Italien, Michael R. Pavia, Fred M. Hershenson, Paul H. Poschel, and John G. Marriott pp 498 - 503; DOI: 10.1021/jm00386a010 |
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Synthesis and structure-activity relationship of 1-aryl-6,8-difluoroquinolone antibacterial agents Daniel T. W. Chu, Prabhavathi B. Fernandes, Robert E. Maleczka, Carl W. Nordeen, and Andre G. Pernet pp 504 - 509; DOI: 10.1021/jm00386a011 |
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Synthesis, biological evaluation, and quantitative structure-activity relationship analysis of 2-hydroxy-1H-isoindolediones as new cytostatic agents Carcy L. Chan, Eric J. Lien, and Zoltan A. Tokes pp 509 - 514; DOI: 10.1021/jm00386a012 |
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Synthesis and 3'-substituent effects of some 7.alpha.-methoxy-1-oxacephems on antibacterial activity and alkaline hydrolysis rates Masayuki Narisada, Junko Nishikawa, Fumihiko Watanabe, and Yoshihiro Terui pp 514 - 522; DOI: 10.1021/jm00386a013 |
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Proton NMR study of degradation mechanisms of oxacephem derivatives with various 3'-substituents in alkaline solution Junko Nishikawa, Fumihiko Watanabe, Masayoshi Shudou, Yoshihiro Terui, and Masayuki Narisada pp 523 - 527; DOI: 10.1021/jm00386a014 |
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Heteroatom-activated .beta.-lactam antibiotics: considerations of differences in the biological activity of [[3(S)-(acylamino)-2-oxo-1-azetidinyl]oxy]acetic acids (oxamazins) and the corresponding sulfur analogs (thiamazins) Donald B. Boyd, Charles Eigenbrot, Joseph M. Indelicato, Marvin J. Miller, Carol E. Pasini, and Steven R. Woulfe pp 528 - 536; DOI: 10.1021/jm00386a015 |
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.alpha.-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model Suvit Thaisrivongs, Donald T. Pals, Judy A. Lawson, Steve R. Turner, and Douglas W. Harris pp 536 - 541; DOI: 10.1021/jm00386a016 |
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Selective cytotoxicity of a system L specific amino acid nitrogen mustard David R. Haines, Richard W. Fuller, Shakeel Ahmad, David T. Vistica, and Victor E. Marquez pp 542 - 547; DOI: 10.1021/jm00386a017 |
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2-[(3-Pyridinylmethyl)thio]pyrimidine derivatives: New bronchosecretolytic agents Helmut Schickaneder, Heidrun Engler, and Istvan Szelenyi pp 547 - 551; DOI: 10.1021/jm00386a018 |
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Synthesis and quantitative structure-activity relationship analysis of N-triiodoallyl- and N-iodopropargylazoles. New antifungal agents Masao Koyama, Noriko Ohtani, Fumio Kai, Ikuo Moriguchi, and Shigeharu Inouye pp 552 - 562; DOI: 10.1021/jm00386a019 |
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Preparation and evaluation of electrophilic derivatives of phenylbutazone as inhibitors of prostaglandin-H-synthase Jonathan L. Vennerstrom and Thomas J. Holmes pp 563 - 567; DOI: 10.1021/jm00386a020 |
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Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy Judith D. Conley and Harold Kohn pp 567 - 574; DOI: 10.1021/jm00386a021 |
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Hydroxamic acid inhibitors of 5-lipoxygenase James B. Summers, Hormoz Mazdiyasni, James H. Holms, James D. Ratajczyk, Richard D. Dyer, and George W. Carter pp 574 - 580; DOI: 10.1021/jm00386a022 |
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Synthesis of D-oxa tricyclic partial ergolines as dopamine agonists Richard N. Booher, Edmund C. Kornfeld, E. Barry Smalstig, and James A. Clemens pp 580 - 583; DOI: 10.1021/jm00386a023 |
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Synthesis and antitumor activity of N-terminal proline-containing peptide-(chloroethyl)nitrosoureas Helga Suli-Vargha, Andras Jeney, Karoly Lapis, and Kalman Medzihradszky pp 583 - 586; DOI: 10.1021/jm00386a024 |
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Antitumor agents. 86. Synthesis and cytotoxicity of .alpha.-methylene-.gamma.-lactone-bearing purines Kuo-Hsiung Lee, Gregory K. Rice, Iris H. Hall, and Venkataraman Amarnath pp 586 - 588; DOI: 10.1021/jm00386a025 |
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Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation Allen Krantz, Robin W. Spencer, Tim F. Tam, Everton Thomas, and Leslie J. Copp pp 589 - 591; DOI: 10.1021/jm00387a001 |
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Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors Gerald S. Ponticello, Mark B. Freedman, Charles N. Habecker, Paulette A. Lyle, Harvey Schwam, Sandor L. Varga, Marcia E. Christy, William C. Randall, and John J. Baldwin pp 591 - 597; DOI: 10.1021/jm00387a002 |
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Linear free energy relationships and cytotoxicities of para-substituted 2-haloethyl aryl selenides and bis(2-chloroethyl) selenides Sang Ihn Kagn and Colin Paul Spears pp 597 - 602; DOI: 10.1021/jm00387a003 |
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Resolved cis- and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists Anette M. Johansson, Lars Erik Arvidsson, Uli Hacksell, J. Lars G. Nilsson, Kjell Svensson, and Arvid Carlsson pp 602 - 611; DOI: 10.1021/jm00387a004 |
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Affinity labels for .beta.-adrenoceptors: preparation and properties of alkylating .beta.-blockers derived from indole Josef Pitha, Wieslaw Buchowiecki, Jan Milecki, and John W. Kusiak pp 612 - 615; DOI: 10.1021/jm00387a005 |
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Role of the (acyloxy)methyl moiety in eliciting the adrenergic .beta.-blocking activity of 3-(acyloxy)propanolamines B. Macchia, A. Balsamo, A. Lapucci, F. Macchia, A. Martinelli, H. L. Ammon, S. M. Prasad, M. C. Breschi, M. Ducci, and E. Martinotti pp 616 - 622; DOI: 10.1021/jm00387a006 |
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Molecular structure of the dihydropyridazinone cardiotonic 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one, a potent inhibitor of cyclic AMP phosphodiesterase David W. Robertson, Noel D. Jones, Joseph H. Krushinski, G. Don Pollock, John K. Swartzendruber, and J. Scott Hayes pp 623 - 627; DOI: 10.1021/jm00387a007 |
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Substituted 1,2,3,4-tetrahydroaminonaphthols: antihypertensive agents, calcium channel blockers, and adrenergic receptor blockers with catecholamine-depleting effects Karnail S. Atwal, Brian C. O'Reilly, Eric P. Ruby, Chester F. Turk, Gunnar Aberg, Magdi M. Asaad, James L. Bergey, Suzanne Moreland, and James R. Powell pp 627 - 635; DOI: 10.1021/jm00387a008 |
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Synthesis and biological activity of novel calcium channel blockers: 2,5-dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters and 2,5-dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic acid esters Karnail S. Atwal, James L. Bergey, Anders Hedberg, and Suzanne Moreland pp 635 - 640; DOI: 10.1021/jm00387a009 |
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Synthesis and calcium channel antagonist activity of dialkyl 4-(dihydropyridinyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates Lina Dagnino, Moy Cheong Li-Kwong-Ken, Hla Wynn, Michael W. Wolowyk, Christopher R. Triggle, and Edward E. Knaus pp 640 - 646; DOI: 10.1021/jm00387a010 |
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Steroidal silicon side-chain analogs as potential antifertility agents Richard H. Peters, David F. Crowe, Masato Tanabe, Mitchell A. Avery, and Wesley K. M. Chong pp 646 - 652; DOI: 10.1021/jm00387a011 |
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Potential antitumor agents. 48. 3'-Dimethylamino derivatives of amsacrine: redox chemistry and in vivo solid tumor activity Graham J. Atwell, Gordon W. Rewcastle, Bruce C. Baguley, and William A. Denny pp 652 - 658; DOI: 10.1021/jm00387a012 |
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Potential antitumor agents. 49. 5-Substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity William A. Denny, Graham J. Atwell, Gordon W. Rewcastle, and Bruce C. Baguley pp 658 - 663; DOI: 10.1021/jm00387a013 |
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Potential antitumor agents. 50. In vivo solid-tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide Graham J. Atwell, Gordon W. Rewcastle, Bruce C. Baguley, and William A. Denny pp 664 - 669; DOI: 10.1021/jm00387a014 |
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Synthesis and tumor uptake of 5-halo-1-(2'-fluoro-2'-deoxy-.beta.-D-ribofuranosyl)[2-14C]uracils John R. Mercer, Edward E. Knaus, and Leonard I. Wiebe pp 670 - 675; DOI: 10.1021/jm00387a015 |
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Folate analogs as inhibitors of thymidylate synthase Diana I. Brixner, Takamori Ueda, Yung Chi Cheng, John B. Hynes, and Arthur D. Broom pp 675 - 678; DOI: 10.1021/jm00387a016 |
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Analogs and derivatives of tenoxicam. 1. Synthesis and antiinflammatory activities of analogs with different residues on the ring nitrogen and the amide nitrogen Dieter Binder, Otto Hromatka, Franz Geissler, Karl Schmied, Christian R. Noe, Kaspar Burri, Rudolf Pfister, Konrad Strub, and Paul Zeller pp 678 - 682; DOI: 10.1021/jm00387a017 |
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Leukotriene receptor antagonists. 1. Synthesis and structure-activity relationships of alkoxyacetophenone derivatives Winston S. Marshall, Theodore Goodson, George J. Cullinan, Dorothy Swanson-Bean, Klaus D. Haisch, Lynn E. Rinkema, and Jerome H. Fleisch pp 682 - 689; DOI: 10.1021/jm00387a018 |
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Diethyl 3,6-dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11-dicarboxylates as calcium entry antagonists: new conformationally restrained analogs of Hantzsch 1,4-dihydropyridines related to nitrendipine as probes for receptor-site conformation John J. Baldwin, David A. Claremon, Patricia K. Lumma, David E. McClure, Seth A. Rosenthal, Raymond J. Winquist, Elizabeth P. Faison, Gregory J. Kaczorowski, Mayme J. Trumble, and Graham M. Smith pp 690 - 695; DOI: 10.1021/jm00387a019 |
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Synthesis and antiarrhythmic activity of novel 3-alkyl-1-[.omega.-[4-[(alkylsulfonyl)amino]phenyl]-.omega.-hydroxyalkyl]-1H-imidazolium salts and related compounds Randall Lis, Thomas K. Morgan, Robert J. DeVita, David D. Davey, William C. Lumma, Ronald A. Wohl, Julius Diamond, Samuel S. Wong, and Mark E. Sullivan pp 696 - 704; DOI: 10.1021/jm00387a020 |
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Inhibition of delayed hypersensitivity reactions by cinnamyl 1-thioglycosides Mitree M. Ponpipom, Robert L. Bugianesi, and Thomas J. Blake pp 705 - 710; DOI: 10.1021/jm00387a021 |
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Structural aspects of ryanodine action and selectivity Andrew L. Waterhouse, Issac N. Pessah, Alexander O. Francini, and John E. Casida pp 710 - 716; DOI: 10.1021/jm00387a022 |
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Comparative antitumor studies on platinum(II) and platinum(IV) complexes containing 1,2-diaminocyclohexane Jean F. Vollano, Salaam Al-Baker, James C. Dabrowiak, and John E. Schurig pp 716 - 719; DOI: 10.1021/jm00387a023 |
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S-[(N,N'-Diarylamidino)methyl] diethyldithiocarbamates and related amides as potential radioprotectants T. Pantev pp 720 - 721; DOI: 10.1021/jm00387a024 |
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.beta.-Adrenoceptor antagonist activity of bivalent ligands. 1. Diamide analogs of practolol. H. Kizuka and R. N. Hanson pp 722 - 726; DOI: 10.1021/jm00387a025 |
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Benzimidazole derivatives with atypical antiinflammatory activity Edward S. Lazer, Martha R. Matteo, and Genus J. Possanza pp 726 - 729; DOI: 10.1021/jm00387a026 |
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Synthesis and binding affinities of analogs of cholecystokinin-(30-33) as probes for central nervous system cholecystokinin receptors David C. Horwell, Andrew Beeby, Colin R. Clark, and John Hughes pp 729 - 732; DOI: 10.1021/jm00387a027 |
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A novel synthesis of colchicide and analogs from thiocolchicine and congeners: reevaluation of colchicide as a potential antitumor agent Raymond Dumont, Arnold Brossi, Colin F. Chignell, Frank R. Quinn, and Matthew Suffness pp 732 - 735; DOI: 10.1021/jm00387a028 |
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Structure-activity studies of antagonists of luteinizing hormone-releasing hormone with emphasis on the amino-terminal region Simon J. Hocart, Mary V. Nekola, and David H. Coy pp 735 - 739; DOI: 10.1021/jm00387a029 |
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Effect of reductive alkylation of D-lysine in position 6 on the histamine-releasing activity of luteinizing hormone-releasing hormone antagonists Simon J. Hocart, Mary V. Nekola, and David H. Coy pp 739 - 743; DOI: 10.1021/jm00387a030 |
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Synthesis and pharmacological evaluation of .gamma.-aminobutyric acid analogs. New ligand for GABAB sites Pascal Berthelot, Claude Vaccher, Amir Musadad, Nathalie Flouquet, Michel Debaert, and Michel Luyckx pp 743 - 746; DOI: 10.1021/jm00387a031 |
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Resolution of racemic carbocyclic analogs of purine nucleosides through the action of adenosine deaminase. Antiviral activity of the carbocyclic 2'-deoxyguanosine enantiomers John A. Secrist, John A. Montgomery, Y. Fulmer Shealy, C. Allen O'Dell, and Sarah Jo Clayton pp 746 - 749; DOI: 10.1021/jm00387a032 |
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Synthesis of 6-substituted .beta.-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists Timothy J. Hagen, Phil Skolnick, and James M. Cook pp 750 - 753; DOI: 10.1021/jm00387a033 |
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Book Reviews pp 753 - 754; DOI: 10.1021/jm00387a600 |
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Rational design of 4-[(methylsulfonyl)amino]benzamides as class III antiarrhythmic agents William C. Lumma Jr., Ronald A. Wohl, David D. Davey, Thomas M. Argentieri, Robert J. DeVita, Robert P. Gomez, Vijay K. Jain, Anthony J. Marisca, Thomas K. Morgan Jr., and et al. pp 755 - 758; DOI: 10.1021/jm00388a001 |
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Synthesis and biological activity of partially modified retro-inverso pseudopeptide derivatives of the C-terminal tetrapeptide of gastrin Marc Rodriguez, Philibert Dubreuil, Jean Pierre Bali, and Jean Martinez pp 758 - 763; DOI: 10.1021/jm00388a002 |
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Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins Alberto Brandt, Marina Cerquetti, G. Bruno Corsi, Giorgio Pascucci, Antonio Simeoni, Paola Martelli, and Umberto Valcavi pp 764 - 767; DOI: 10.1021/jm00388a003 |
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The metabolism of carbamazepine in humans: steric course of the enzymic hydrolysis of the 10,11-epoxide Giuseppe Bellucci, Giancarlo Berti, Cinzia Chiappe, Annalisa Lippi, and Franco Marioni pp 768 - 773; DOI: 10.1021/jm00388a004 |
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Synthesis and antiarrhythmic activity of new 3-[2-(.omega.-aminoalkoxy)phenoxy]-4-phenyl-3-buten-2-ones and related compounds Aldo Salimbeni, Elso Manghisi, Giancarlo B. Fregnan, and Marco Prada pp 773 - 780; DOI: 10.1021/jm00388a005 |
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Synthesis and antiarrhythmic properties of novel 3-selena-7-azabicyclo[3.3.1]nonanes and derivatives. Single-crystal x-ray diffraction analysis of 7-benzyl-3-selena-7-azabicyclo[3.3.1]nonan-9-one and 7-benzyl-3-selena-7-azabicyclo[3.3.1]nonane hydroperchlorate M. Daniel Thompson, Gary S. Smith, K. Darrell Berlin, Elizabeth M. Holt, Benjamin J. Scherlag, Dick Van der Helm, Steven W. Muchmore, and Krzysztof A. Fidelis pp 780 - 788; DOI: 10.1021/jm00388a006 |
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Flavones. 1. Synthesis and antihypertensive activity of (3-phenylflavonoxy)propanolamines without .beta.-adrenoceptor antagonism E. S. C. Wu, T. E. Cole, T. A. Davidson, J. C. Blosser, A. R. Borrelli, C. R. Kinsolving, T. E. Milgate, and R. B. Parker pp 788 - 792; DOI: 10.1021/jm00388a007 |
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Structure-activity relationship in PAF-acether. 3. Hydrophobic contribution to agonistic activity Jean Jacques Godfroid, Colette Broquet, Simone Jouquey, Mariya Lebbar, Francoise Heymans, Catherine Redeuilh, Efroim Steiner, Elie Michel, Eliane Coeffier, and et al. pp 792 - 797; DOI: 10.1021/jm00388a008 |
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Resolution, absolute stereochemistry, and enantioselective activity of nomifensine and hexahydro-1H-indeno[1,2-b]pyridines Rudolf Kunstmann, Hermann Gerhards, Hansjoerg Kruse, Margret Leven, Erich F. Paulus, Ulrich Schacht, Karl Schmitt, and Peter U. Witte pp 798 - 804; DOI: 10.1021/jm00388a009 |
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6-Methyl-6-azabicyclo[3.2.1]octan-3.alpha.-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent F. Ivy Carroll, Philip Abraham, Karol Parham, Ronald C. Griffith, Ateeq Ahmad, Michelle M. Richard, Felipe N. Padilla, Jeffrey M. Witkin, and Peter K. Chiang pp 805 - 809; DOI: 10.1021/jm00388a010 |
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Synthesis of new heparinoids with high anticoagulant activity Kenichi Hatanaka, Takashi Yoshida, Shintaro Miyahara, Takahiro Sato, Fujihiko Ono, Toshiyuki Uryu, and Hiroyoshi Kuzuhara pp 810 - 814; DOI: 10.1021/jm00388a011 |
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Synthesis and neuroleptic activity of a series of 1-[1-(benzo-1,4-dioxan-2-ylmethyl)-4-piperidinyl]benzimidazolone derivatives Rainer Henning, Rudolf Lattrell, Hermann J. Gerhards, and Margret Leven pp 814 - 819; DOI: 10.1021/jm00388a012 |
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Synthesis and antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids. The 6-substituted compounds. Joseph M. Muchowski, Gary F. Cooper, Otto Halpern, Richard Koehler, Arthur F. Kluge, Robert L. Simon, Stefan H. Unger, Albert R. Van Horn, Douglas L. Wren, and et al. pp 820 - 823; DOI: 10.1021/jm00388a013 |
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Dihydropyridazinone cardiotonics: synthesis and inotropic activity of 5'-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-spiro[cycloalkane-1,3'-[3H]indol]-2'(1'H)-ones David W. Robertson, Joseph H. Krushinski, G. Don Pollock, Harve Wilson, Raymond F. Kauffman, and J. Scott Hayes pp 824 - 829; DOI: 10.1021/jm00388a014 |
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Estrogenic affinity labels: synthesis, irreversible receptor binding, and bioactivity of aziridine-substituted hexestrol derivatives Jeffery A. Zablocki, John A. Katzenellenbogen, Kathryn E. Carlson, M. J. Norman, and Benita S. Katzenellenbogen pp 829 - 838; DOI: 10.1021/jm00388a015 |
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Synthesis, absolute configuration, and antibacterial activity of 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid John F. Gerster, Steve R. Rohlfing, Sharon E. Pecore, Richard M. Winandy, Richard M. Stern, June E. Landmesser, Roger A. Olsen, and William B. Gleason pp 839 - 843; DOI: 10.1021/jm00388a016 |
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Potential antitumor agents. 51. Synthesis and antitumor activity of substituted phenazine-1-carboxamides Gordon W. Rewcastle, William A. Denny, and Bruce C. Baguley pp 843 - 851; DOI: 10.1021/jm00388a017 |
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Kinetics of solvolysis and muscarinic actions of a (2-bromoethyl)methylamino analog of oxotremorine Bjorn Ringdahl and Donald J. Jenden pp 852 - 854; DOI: 10.1021/jm00388a018 |
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Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents Laurence P. G. Wakelin, Graham J. Atwell, Gordon W. Rewcastle, and William A. Denny pp 855 - 861; DOI: 10.1021/jm00388a019 |
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Potential anti-AIDS drugs. 2',3'-Dideoxycytidine analogs Chong Ho Kim, Victor E. Marquez, Samuel Broder, Hiroaki Mitsuya, and John S. Driscoll pp 862 - 866; DOI: 10.1021/jm00388a020 |
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1-(2-Deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent Muzammil M. Mansuri, Ismail Ghazzouli, Ming S. Chen, Henry G. Howell, Paul R. Brodfuehrer, Daniel A. Benigni, and John C. Martin pp 867 - 871; DOI: 10.1021/jm00388a021 |
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Structure-activity relationships in the 2-arylcarbapenem series. Synthesis of 1-methyl-2-arylcarbapenems Ravindra Nath Guthikonda, L. D. Cama, M. Quesada, M. F. Woods, T. N. Salzmann, and B. G. Christensen pp 871 - 880; DOI: 10.1021/jm00388a022 |
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Anticonvulsant O-alkyl sulfamates. 2,3:4,5-Bis-O-(1-methylethylidene)-.beta.-D-fructopyranose sulfamate and related compounds Bruce E. Maryanoff, Samuel O. Nortey, Joseph F. Gardocki, Richard P. Shank, and Susanna P. Dodgson pp 880 - 887; DOI: 10.1021/jm00388a023 |
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Isozyme-specific enzyme inhibitors. 13. S-[5'(R)-['N-triphosphoamino)methyl]adenosyl]-L-homocysteine, a potent inhibitor of rat methionine adenosyltransferases Vivekananda M. Vrudhula, Francis Kappler, and Alexander Hampton pp 888 - 894; DOI: 10.1021/jm00388a024 |
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Antisecretory activity of human, dog, and rat metabolites of fenoctimine Malcolm K. Scott, Henry I. Jacoby, Antoinette C. Bonfilio, Thomas W. Corcoran, and Iris S. Lopez pp 894 - 899; DOI: 10.1021/jm00388a025 |
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A quantitative structure-activity relationship analysis of some 4-aminodiphenyl sulfone antibacterial agents using linear free energy and molecular modeling methods Rosa L. Lopez de Compadre, R. A. Pearlstein, A. J. Hopfinger, and J. K. Seydel pp 900 - 906; DOI: 10.1021/jm00388a026 |
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Antimalarial drugs. 61. Synthesis and antimalarial effects of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-alkylphenols and their N.omega.-oxides Stephen J. Kesten, Judith Johnson, and Leslie M. Werbel pp 906 - 911; DOI: 10.1021/jm00388a027 |
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Leukotriene receptor antagonists. 2. The [[(tetrazol-5-ylaryl)oxy]methyl]acetophenone derivatives Robert D. Dillard, F. Patrick Carr, Doris McCullough, Klaus D. Haisch, Lynn E. Rinkema, and Jerome H. Fleisch pp 911 - 918; DOI: 10.1021/jm00388a028 |
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Preparation and biological evaluation of a potential photoaffinity label for the prostaglandin H2/thromboxane A2 receptor S. K. Arora, E. J. Kattelman, C. T. Lim, G. C. Le Breton, and D. L. Venton pp 918 - 924; DOI: 10.1021/jm00388a029 |
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Nucleosides. 141. Synthesis of 5-.beta.-D-ribofuranosylnicotinamide and its N-methyl derivative. The isosteric and isoelectronic analogs of nicotinamide nucleoside Marek M. Kabat, Krzysztof W. Pankiewicz, and Kyoichi A. Watanabe pp 924 - 927; DOI: 10.1021/jm00388a030 |
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Reactive 5'-substituted 2',5'-dideoxyuridine derivatives as potential inhibitors of nucleotide biosynthesis Robert D. Elliott, Pamela S. Pruett, R. Wallace Brockman, and John A. Montgomery pp 927 - 930; DOI: 10.1021/jm00388a031 |
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N-Methyl derivatives of the 5-HT2 agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane Richard A. Glennon, Milt Titeler, Mark Seggel, and Robert A. Lyon pp 930 - 932; DOI: 10.1021/jm00388a032 |
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Opioid agonist and antagonist activities of monofunctional nitrogen mustard analogs of .beta.-chlornaltrexamine (.beta.-CNA) J. W. Schoenecker, A. E. Takemori, and P. S. Portoghese pp 933 - 935; DOI: 10.1021/jm00388a033 |
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O-Carbamoylsalicylates: agents for modification of hemoglobins Kumarapuram N. Parameswaran, Guey Yeh Shi, and Irving M. Klotz pp 936 - 939; DOI: 10.1021/jm00388a034 |
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Imidazole anticonvulsants: structure-activity relationships of [(biphenylyloxy)alkyl]imidazoles David W. Robertson, E. E. Beedle, Ron Lawson, and J. David Leander pp 939 - 943; DOI: 10.1021/jm00388a035 |
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Synthesis and biological activity of unsaturated carboacyclic purine nucleoside analogs David R. Haines, Christopher K. H. Tseng, and Victor E. Marquez pp 943 - 947; DOI: 10.1021/jm00388a036 |
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Hexahydro-1H-1-pyrindines from acid rearrangement of 9-alkylidene-5-(m-methoxyphenyl)-2-methylmorphans. Structural type of narcotic antagonists Hiroyoshi Awaya, Everette L. May, Mario D. Aceto, Louis S. Harris, James V. Silverton, Kenner C. Rice, Mariena V. Mattson, and Arthur E. Jacobson pp 947 - 950; DOI: 10.1021/jm00388a037 |
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Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 3. Guanidines Christopher B. Chapleo, Peter L. Myers, Alan C. B. Smith, Ian F. Tulloch, and Donald S. Walter pp 951 - 954; DOI: 10.1021/jm00388a038 |
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N6-Phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors Madan M. Kwatra, Edward Leung, M. Marlene Hosey, and Richard D. Green pp 954 - 956; DOI: 10.1021/jm00388a039 |
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Book Reviews pp 956 - 958; DOI: 10.1021/jm00388a600 |
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High-affinity leukotriene receptor antagonists. Synthesis and pharmacological characterization of 2-hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl]propanoic acid John G. Gleason, Ralph F. Hall, Carl D. Perchonock, Karl F. Erhard, James S. Frazee, Thomas W. Ku, Karen Kondrad, Mary E. McCarthy, Seymour Mong, and et al. pp 959 - 961; DOI: 10.1021/jm00389a001 |
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Investigation of peripheral cholecystokinin receptor heterogeneity by cyclic and related linear analogs of CCK26-33. Synthesis and biological properties Bruno Charpentier, Christiane Durieux, Isabelle Menant, and Bernard P. Roques pp 962 - 968; DOI: 10.1021/jm00389a002 |
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Synthesis and characterization of all four isomers of the muscarinic agonist, 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane] John Saunders, Graham A. Showell, Raymond Baker, Stephen B. Freedman, David Hill, Alexander McKnight, Nigel Newberry, John D. Salamone, Jordan Hirshfield, and James P. Springer pp 969 - 975; DOI: 10.1021/jm00389a003 |
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Renin inhibitors. Design of angiotensinogen transition-state analogs containing novel (2R,3R,4R,5S)-5-amino-3,4-dihydroxy-2-isopropyl-7-methyloctanoic acid Suvit Thaisrivongs, Donald T. Pals, Lisa T. Kroll, Steve R. Turner, and Fu Son Han pp 976 - 982; DOI: 10.1021/jm00389a004 |
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Systematic synthesis and biological evaluation of .alpha.- and .beta.-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases Gilles Gosselin, Marie Christine Bergogne, Jean De Rudder, Erik De Clercq, and Jean Louis Imbach pp 982 - 991; DOI: 10.1021/jm00389a005 |
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Synthesis and structure activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids C. J. Blankley, J. S. Kaltenbronn, D. E. DeJohn, A. Werner, L. R. Bennett, G. Bobowski, U. Krolls, D. R. Johnson, and W. M. Pearlman pp 992 - 998; DOI: 10.1021/jm00389a006 |
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2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) derivatives as .alpha.1-adrenoceptor antagonists and antihypertensive agents Valerie A. Alabaster, Simon F. Campbell, John C. Danilewicz, Colin W. Greengrass, and Rhona M. Plews pp 999 - 1003; DOI: 10.1021/jm00389a007 |
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Synthesis of a series of compounds related to betaxolol, a new .beta.1-adrenoceptor antagonist with a pharmacological and pharmacokinetic profile optimized for the treatment of chronic cardiovascular diseases Philippe M. Manoury, Jean L. Binet, Jean Rousseau, Francoise M. Lefevre-Borg, and Icilio G. Cavero pp 1003 - 1011; DOI: 10.1021/jm00389a008 |
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Conformationally defined adrenergic agents. 5. Resolution, absolute configuration, and pharmacological characterization of the enantiomers of 2-(5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthyl)imidazoline: a potent agonist at .alpha.-adrenoceptors John F. DeBernardis, Daniel J. Kerkman, David L. Arendsen, Steve A. Buckner, John J. Kyncl, and Arthur A. Hancock pp 1011 - 1017; DOI: 10.1021/jm00389a009 |
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Inhibition of human sputum elastase by substituted 2-pyrones. 2 Luisa Cook, Bela Ternai, and Peter Ghosh pp 1017 - 1023; DOI: 10.1021/jm00389a010 |
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Cardiotonic agents. 5. 1,2-Dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-6-methyl-2-oxo-3-pyridinecarbonitriles and related compounds. Synthesis and inotropic activity Ila Sircar, Bradley L. Duell, James A. Bristol, Ronald E. Weishaar, and Dale B. Evans pp 1023 - 1029; DOI: 10.1021/jm00389a011 |
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Selective thromboxane synthetase inhibitors and antihypertensive agents. New derivatives of 4-hydrazino-5H-pyridazino[4,5-b]indole, 4-hydrazinotriazino[4,5-a]indole, and related compounds A. Monge, P. Parrado, M. Font, and E. Fernandez-Alvarez pp 1029 - 1035; DOI: 10.1021/jm00389a012 |
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Thromboxane synthetase inhibitors and antihypertensive agents. 3. N-[(1H-imidazol-1-yl)alkyl]heteroaryl amides as potent enzyme inhibitors Jeffery B. Press, William B. Wright, Peter S. Chan, Margie F. Haug, Joseph W. Marsico, and Andrew S. Tomcufcik pp 1036 - 1040; DOI: 10.1021/jm00389a013 |
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Nonequilibrium opioid antagonist activity of 6,14-dideoxynaltrexone derivatives J. W. Schoenecker, A. E. Takemori, and P. S. Portoghese pp 1040 - 1044; DOI: 10.1021/jm00389a014 |
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Synthesis, structure, and biological activity of certain 2-deoxy-.beta.-D-ribo-hexopyranosyl nucleosides and nucleotides L. Dee Nord, N. Kent Dalley, Patricia A. McKernan, and Roland K. Robins pp 1044 - 1054; DOI: 10.1021/jm00389a015 |
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Synthesis and oral antifungal activity of novel azolylpropanolones and related compounds Masaru Ogata, Hiroshi Matsumoto, Kimio Takahashi, Sumio Shimizu, Shiro Kida, Akira Murabayashi, Motoo Shiro, and Katsuya Tawara pp 1054 - 1068; DOI: 10.1021/jm00389a016 |
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Synthesis and structure-activity studies of corticosteroid 17-heterocyclic aromatic esters. 1. 9.alpha.,11.beta.-Dichloro series Elliot L. Shapiro, Margaret J. Gentles, Robert L. Tiberi, Thomas L. Popper, Joseph Berkenkopf, Barry Lutsky, and Arthur S. Watnick pp 1068 - 1073; DOI: 10.1021/jm00389a017 |
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Inhibition of the mammalian .beta.-lactamase renal dipeptidase (dehydropeptidase-I) by Z-2-(acylamino)-3-substituted-propenoic acids Donald W. Graham, Wallace T. Ashton, Louis Barash, Jeannette E. Brown, Ronald D. Brown, Laura F. Canning, Anna Chen, James P. Springer, and Edward F. Rogers pp 1074 - 1090; DOI: 10.1021/jm00389a018 |
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Synthesis and antiviral evaluation of carbocyclic analogs of 2-amino-6-substituted-purine 3'-deoxyribofuranosides Y. Fulmer Shealy, C. Allen O'Dell, and Gussie Arnett pp 1090 - 1094; DOI: 10.1021/jm00389a019 |
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Resolution of (.+-.)-2-tetradecyloxiranecarboxylic acid. Absolute configuration and chiral synthesis of the hypoglycemic R enantiomer and biological activity of enantiomers Winston Ho, Okan Tarhan, Timothy C. Kiorpes, Gene F. Tutwiler, and Richard J. Mohrbacher pp 1094 - 1097; DOI: 10.1021/jm00389a020 |
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Long-acting angiotensin II inhibitors containing hexafluorovaline in position 8 Kun Hwa Hsieh, Philip Needleman, and Garland R. Marshall pp 1097 - 1100; DOI: 10.1021/jm00389a021 |
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Psychotropic agents: synthesis and antipsychotic activity of substituted .beta.-carbolines Magid Abou-Gharbia, Usha R. Patel, John A. Moyer, and Eric A. Muth pp 1100 - 1105; DOI: 10.1021/jm00389a022 |
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2-Amino- and 2-guanidino-1,2,3,4-tetrahydro-1,4-epoxynaphthalenes as conformationally defined analogs of .alpha.-adrenergic agents Edward C. R. Smith, Thomas N. Riley, Ronald F. Borne, and I. W. Waters pp 1105 - 1110; DOI: 10.1021/jm00389a023 |
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Spectroscopic detection of iminocyclophosphamide and its possible role in cyclophosphamide metabolism Chul Hoon Kwon, Marion C. Kirk, Robert F. Struck, and Richard F. Borch pp 1110 - 1114; DOI: 10.1021/jm00389a024 |
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Conformational analysis of 2-aminoindans and 2-(aminomethyl)indans in relation to their central dopaminergic effects and a dynamic dopamine receptor concept Hakan Wikstrom, Jenn-Huei Lii, and Norman L. Allinger pp 1115 - 1120; DOI: 10.1021/jm00390a001 |
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The role of solvent-accessible surface area in determining partition coefficients W. J. Dunn, M. G. Koehler, and Stelian Grigoras pp 1121 - 1126; DOI: 10.1021/jm00390a002 |
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Peptide quantitative structure-activity relationships, a multivariate approach Sven Hellberg, Michael Sjoestroem, Bert Skagerberg, and Svante Wold pp 1126 - 1135; DOI: 10.1021/jm00390a003 |
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C3-Methylated 5-hydroxy-2-(dipropylamino)tetralins: conformational and steric parameters of importance for central dopamine receptor activation Anette M. Johansson, J. Lars G. Nilsson, Anders Karlen, Uli Hacksell, Kjell Svensson, Arvid Carlsson, Lennart Kenne, and Staffan Sundell pp 1135 - 1144; DOI: 10.1021/jm00390a004 |
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N,N-Dialkylated leucine enkephalins as potential .delta. opioid receptor antagonists Jane A. Lovett and Philip S. Portoghese pp 1144 - 1149; DOI: 10.1021/jm00390a005 |
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Zwitterionic analogs of cimetidine as H2 receptor antagonists Rodney C. Young, C. Robin Ganellin, Michael J. Graham, Robert C. Mitchell, Michael L. Roantree, and Zev Tashma pp 1150 - 1156; DOI: 10.1021/jm00390a006 |
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A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives Hiromi Okushima, Akihiro Narimatsu, Makio Kobayashi, Rikizo Furuya, Kunio Tsuda, and Yoshimi Kitada pp 1157 - 1161; DOI: 10.1021/jm00390a007 |
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Solid-phase synthesis and biological properties of .psi.[CH2NH] pseudopeptide analogs of a highly potent somatostatin octapeptide Yusuke Sasaki, William A. Murphy, Mark L. Heiman, Valentine A. Lance, and David H. Coy pp 1162 - 1166; DOI: 10.1021/jm00390a008 |
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Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent: benzothiazol-2-one 7-ethylamines Joseph Weinstock, Dimitri E. Gaitanopoulos, Orum D. Stringer, Robert G. Franz, J. Paul Hieble, Lewis B. Kinter, William A. Mann, Kathryn E. Flaim, and George Gessner pp 1166 - 1176; DOI: 10.1021/jm00390a009 |
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Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogs Francis A. J. Kerdesky, Steven P. Schmidt, James H. Holms, Richard D. Dyer, George W. Carter, and Dee W. Brooks pp 1177 - 1186; DOI: 10.1021/jm00390a010 |
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Structure-activity relationships among di- and tetramine disulfides related to benextramine M. Alvarez, R. Granados, D. Mauleon, G. Rosell, M. Salas, J. Salles, and N. Valls pp 1186 - 1193; DOI: 10.1021/jm00390a011 |
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Modifications of primaquine as antimalarials. 4. 5-Alkoxy derivatives of primaquine Eugene H. Chen, Keiichi Tanabe, Andrew J. Saggiomo, and Edward A. Nodiff pp 1193 - 1199; DOI: 10.1021/jm00390a012 |
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2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity Herfried Griengl, Erich Wanek, Wolfgang Schwarz, Wolfgang Streicher, Brigitte Rosenwirth, and Erik De Clercq pp 1199 - 1204; DOI: 10.1021/jm00390a013 |
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Synthesis and biological properties of some 6H-pyrido[4,3-b]carbazoles Sydney Archer, Bruce S. Ross, Livia Pica-Mattoccia, and Donato Cioli pp 1204 - 1210; DOI: 10.1021/jm00390a014 |
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N,N-Disubstituted 6-alkoxy-2-pyridinamines as anticonvulsant agents Michael R. Pavia, Charles P. Taylor, Fred M. Hershenson, and Sandra J. Lobbestael pp 1210 - 1214; DOI: 10.1021/jm00390a015 |
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Synthesis and anticonvulsant activity of analogs of 4-amino-N-(1-phenylethyl)benzamide C. Randall Clark and Timothy W. Davenport pp 1214 - 1218; DOI: 10.1021/jm00390a016 |
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Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth Raymond G. Booth, Cynthia Dias Selassie, Corwin Hansch, and Daniel V. Santi pp 1218 - 1224; DOI: 10.1021/jm00390a017 |
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Novel renin inhibitors containing analogs of statine retro-inverted at the C-termini. Specificity at the P2 histidine site Saul H. Rosenberg, Jacob J. Plattner, Keith W. Woods, Herman H. Stein, Patrick A. Marcotte, Jerome Cohen, and Thomas J. Perun pp 1224 - 1228; DOI: 10.1021/jm00390a018 |
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Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists B. E. Evans, K. E. Rittle, M. G. Bock, R. M. DiPardo, R. M. Freidinger, W. L. Whitter, N. P. Gould, G. F. Lundell, C. F. Homnick, and et al. pp 1229 - 1239; DOI: 10.1021/jm00390a019 |
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Chemical and enzymatic oxidative coupling of 5-hydroxy-N-dimethyltryptamine with amines Fabienne Babin and Tam Huynh-Dinh pp 1239 - 1241; DOI: 10.1021/jm00390a020 |
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Radioiodinated p-iodoclonidine. A high-affinity probe for the .alpha.2-adrenergic receptor M. Van Dort, R. Neubig, and R. E. Counsell pp 1241 - 1244; DOI: 10.1021/jm00390a021 |
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Synthesis and antitumor activity of tropolone derivatives. 5 Masatoshi Yamato, Kuniko Hashigaki, Junko Sakai, Yasuo Takeuchi, Shigeru Tsukagoshi, Tazuko Tashiro, and Takashi Tsuruo pp 1245 - 1248; DOI: 10.1021/jm00390a022 |
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Synthesis of .beta.-carboline-benzodiazepine hybrid molecules: use of the known structural requirements for benzodiazepine and .beta.-carboline binding in designing a novel, high-affinity ligand for the benzodiazepine receptor Robert H. Dodd, Catherine Ouannes, Marie Claude Potier, Lia Prado de Carvalho, Jean Rossier, and Pierre Potier pp 1248 - 1254; DOI: 10.1021/jm00390a023 |
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N10-Substituted 5,8-dideazafolate inhibitors of glycinamide ribonucleotide transformylase Carol A. Caperelli pp 1254 - 1256; DOI: 10.1021/jm00390a024 |
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Folate analogs. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds. M. G. Nair, Rashmi Dhawan, M. Ghazala, T. I. Kalman, Y. Gaumont, R. L. Kisliuk, and R. Ferone pp 1256 - 1261; DOI: 10.1021/jm00390a025 |
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Additions and Corrections-Enantiomers of 3-(3,4-Dihydroxyphenyl)- and 3-(3-Hydroxyphenyl)-N-n-propylpiperdine: Central Pre- and Postsynaptic Dopaminergic Effects and Pharmacokinetics Hans Rollema, Dora Mastebroek, Hakan Wikstrom, Kjell Svensson, Arvid Carlsson, and Staffan Sundell pp 1261 - 1261; DOI: 10.1021/jm00390a600 |
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Book Reviews pp 1262 - 1264; DOI: 10.1021/jm00390a601 |
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Dissociation of hypolipidemic and antiplatelet actions from adverse myotonic effects of clofibric acid related enantiomers Dennis R. Feller, Vaijinath S. Kamanna, Howard A. I. Newman, Karl J. Romstedt, Donald T. Witiak, Giancarlo Bettoni, Shirley H. Bryant, Diana Conte-Camerino, Fulvio Loiodice, and Vincenzo Tortorella pp 1265 - 1267; DOI: 10.1021/jm00391a001 |
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Stereospecificity of the chloride ion channel: the action of chiral clofibric acid analogs Giancarlo Bettoni, Fulvio Loiodice, Vincenzo Tortorella, Diana Conte-Camerino, Mercede Mambrini, Ermanno Ferrannini, and Shirley H. Bryant pp 1267 - 1270; DOI: 10.1021/jm00391a002 |
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3'-Substituted 2',3'-dideoxynucleoside analogs as potential anti-HIV (HTLV-III/LAV) agents Piet Herdewijn, Jan Balzarini, Erik De Clercq, Rudi Pauwels, Masanori Baba, Samuel Broder, and Hubert Vanderhaeghe pp 1270 - 1278; DOI: 10.1021/jm00391a003 |
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Nonsteroidal cardiotonics. 1. 2-Pyridyl-6,7-dihydro-3H,5H-pyrrolo[2,3-f]benzimidazol-6-ones, a novel class of cardiotonic agents A. Mertens, B. Mueller-Beckmann, W. Kampe, J. P. Hoelck, and W. Von der Saal pp 1279 - 1287; DOI: 10.1021/jm00391a004 |
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Analysis of structure-activity relationships in renin substrate analog inhibitory peptides Kwan Y. Hui, William D. Carlson, Michael S. Bernatowicz, and Edgar Haber pp 1287 - 1295; DOI: 10.1021/jm00391a005 |
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Limited nerve impulse blockade by "leashed" local anesthetics John F. Butterworth, John R. Moran, George M. Whitesides, and Gary R. Strichartz pp 1295 - 1302; DOI: 10.1021/jm00391a006 |
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Synthesis, conformation, and dopaminergic activity of 5,6-ethano-bridged derivatives of selective dopaminergic 3-benzazepines Joseph Weinstock, Hye Ja Oh, Charles W. DeBrosse, Drake S. Eggleston, Margaret Wise, Kathryn E. Flaim, George W. Gessner, John L. Sawyer, and Carl Kaiser pp 1303 - 1308; DOI: 10.1021/jm00391a007 |
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Inhibitors of dopamine .beta.-hydroxylase. 3. Some 1-(pyridylmethyl)imidazole-2-thiones Stephen T. Ross, Lawrence I. Kruse, Eliot H. Ohlstein, Robert W. Erickson, Mildred Ezekiel, Kathryn E. Flaim, John L. Sawyer, and Barry A. Berkowitz pp 1309 - 1313; DOI: 10.1021/jm00391a008 |
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New antitumor agents containing the anthracene nucleus Timothy P. Wunz, Robert T. Dorr, David S. Alberts, Cynthia L. Tunget, Janine Einspahr, Sharlene Milton, and William A. Remers pp 1313 - 1321; DOI: 10.1021/jm00391a009 |
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Antianaphylactic benzophenones and related compounds Delme Evans, Mark E. Cracknell, John C. Saunders, Christine E. Smith, W. R. Nigel Williamson, William Dawson, and W. John F. Sweatman pp 1321 - 1327; DOI: 10.1021/jm00391a010 |
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Stereocontrolled syntheses for the six diastereomeric 1,2-dihydroxy-4,5-diaminocyclohexanes: PtII complexes and P-388 antitumor properties Donald T. Witiak, David P. Rotella, Joyce A. Filippi, and Judith Gallucci pp 1327 - 1336; DOI: 10.1021/jm00391a011 |
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Cardiotonic agents. 1. Novel 8-aryl substituted imidazo[1,2-a]- and -[1,5-a]pyridines and imidazo[1,5-a]pyridinones as potential positive inotropic agents David Davey, Paul W. Erhardt, William C. Lumma, Jay Wiggins, Mark Sullivan, David Pang, and Elinor Cantor pp 1337 - 1342; DOI: 10.1021/jm00391a012 |
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Cardiotonic agents. 2. (Imidazolyl)aroylimidazolones, highly potent and selective positive inotropic agents Alfred A. Hagedorn, III, Paul W. Erhardt, William C. Lumma Jr., Ronald A. Wohl, Elinor Cantor, Yuo Ling Chou, William R. Ingebretsen, John W. Lampe, David Pang, and et al. pp 1342 - 1347; DOI: 10.1021/jm00391a013 |
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Synthesis and antifungal activity of new 1-vinylimidazoles Masaru Ogata, Hiroshi Matsumoto, Sumio Shimizu, Shiro Kida, Motoo Shiro, and Katsuya Tawara pp 1348 - 1354; DOI: 10.1021/jm00391a014 |
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Berbanes: a new class of selective .alpha.2-adrenoceptor antagonists E. Sylvester Vizi, Istvan Toth, George T. Somogyi, Lajos Szabo, Laszlo G. Harsing, and Csaba Szantay pp 1355 - 1359; DOI: 10.1021/jm00391a015 |
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Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines Harold M. Taylor, C. David Jones, James D. Davenport, Kenneth S. Hirsch, T. J. Kress, and Dix Weaver pp 1359 - 1365; DOI: 10.1021/jm00391a016 |
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Synthesis and biological activities of pseudopeptide analogs of the C-terminal heptapeptide of cholecystokinin. On the importance of the peptide bonds Marc Rodriguez, Marie Francoise Lignon, Marie Christine Galas, Pierre Fulcrand, Christiane Mendre, Andre Aumelas, Jeanine Laur, and Jean Martinez pp 1366 - 1373; DOI: 10.1021/jm00391a017 |
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.beta.-Substituted cysteines as sequestering agents for ethanol-derived acetaldehyde in vivo Herbert T. Nagasawa, James A. Elberling, and Jeanette C. Roberts pp 1373 - 1378; DOI: 10.1021/jm00391a018 |
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Tricyclic compounds as selective antimuscarinics. 1. Structural requirements for selectivity towards the muscarinic acetylcholine receptor in a series of pirenzepine and imipramine analogs Wolfgang G. Eberlein, Guenter Trummlitz, Wolfhard W. Engel, Guenther Schmidt, Helmut Pelzer, and Norbert Mayer pp 1378 - 1382; DOI: 10.1021/jm00391a019 |
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Synthesis of glycopyranosylphosphonate analogs of certain natural nucleoside diphosphate sugars as potential inhibitors of glycosyltransferases Morteza M. Vaghefi, Ralph J. Bernacki, N. Kent Dalley, Bruce E. Wilson, and Roland K. Robins pp 1383 - 1391; DOI: 10.1021/jm00391a020 |
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Synthesis of certain nucleoside methylenediphosphonate sugars as potential inhibitors of glycosyltransferases Morteza M. Vaghefi, Ralph J. Bernacki, William J. Hennen, and Roland K. Robins pp 1391 - 1399; DOI: 10.1021/jm00391a021 |
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Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice Luke K. T. Lam, Velta L. Sparnins, and Lee W. Wattenberg pp 1399 - 1403; DOI: 10.1021/jm00391a022 |
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Aldosterone antagonists. 2. New 7.alpha.-(acetylthio)-15,16-methylene spirolactones Klaus Nickisch, Dieter Bittler, Henry Laurent, Wolfgang Losert, Jorge Casals-Stenzel, Yukishige Nishino, Ekkehard Schillinger, and Rudolf Wiechert pp 1403 - 1409; DOI: 10.1021/jm00391a023 |
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Synthesis of two glucagon antagonists: receptor binding, adenylate cyclase, and effects on blood plasma glucose levels Beat Gysin, David G. Johnson, Dev Trivedi, and Victor J. Hruby pp 1409 - 1415; DOI: 10.1021/jm00391a024 |
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Amplification of bleomycin-mediated degradation of DNA L. Strekowski, A. Strekowska, R. A. Watson, F. A. Tanious, L. T. Nguyen, and W. D. Wilson pp 1415 - 1420; DOI: 10.1021/jm00391a025 |
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Synthesis and cardiotonic activity of a series of substituted 4-alkyl-2(1H)-quinazolinones Victor T. Bandurco, Charles F. Schwender, Stanley C. Bell, Donald W. Combs, Ramesh M. Kanojia, Seymour D. Levine, Dennis M. Mulvey, Mary A. Appollina, Marianne S. Reed, and et al. pp 1421 - 1426; DOI: 10.1021/jm00391a026 |
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gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity Nguyen Lan Mong, Eric Niesor, and Craig L. Bentzen pp 1426 - 1433; DOI: 10.1021/jm00391a027 |
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Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships Bruce E. Maryanoff, David F. McComsey, Joseph F. Gardocki, Richard P. Shank, Michael J. Costanzo, Samuel O. Nortey, Craig R. Schneider, and Paulette E. Setler pp 1433 - 1454; DOI: 10.1021/jm00391a028 |
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Specific dopamine D-1 and DA1 properties of 4-(mono- and -dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline and its tetrahydrothieno[2,3c]pyridine analog Robert M. Riggs, David E. Nichols, Mark M. Foreman, Lewis L. Truex, Dana Glock, and Jai D. Kohli pp 1454 - 1458; DOI: 10.1021/jm00391a029 |
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Chemistry of emeriamine and its analogs and their inhibitory activity in long-chain fatty acid oxidation Susumu Shinagawa, Tsuneo Kanamaru, Setsuo Harada, Mitsuko Asai, and Hisayoshi Okazaki pp 1458 - 1463; DOI: 10.1021/jm00391a030 |
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Methotrexate analogs. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N.epsilon.-(haloacetyl)-L-lysine and N.delta.-(haloacetyl)-L-ornithine analogs and an acivicin analog of methotrexate Andre Rosowsky, Vishnu C. Solan, Ronald A. Forsch, Tavner J. Delcamp, David P. Baccanari, and James H. Freisheim pp 1463 - 1469; DOI: 10.1021/jm00391a031 |
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Synthesis and .beta.-lactamase inhibitory properties of 2.beta.-[(1,2,3-triazol-1-yl)methyl]-2.alpha.-methylpenam-3.alpha.-carboxylic acid 1,1-dioxide and related triazolyl derivatives Ronald G. Micetich, Samarendra N. Maiti, Paul Spevak, Tse W. Hall, Shigeru Yamabe, Naobumi Ishida, Motoaki Tanaka, Tomio Yamazaki, Akira Nakai, and Kazuo Ogawa pp 1469 - 1474; DOI: 10.1021/jm00391a032 |
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Heteroarotinoids. Synthesis, characterization, and biological activity in terms of an assessment of these systems to inhibit the induction of ornithine decarboxylase activity and to induce terminal differentiation of HL-60 cells Lyle W. Spruce, Shirish N. Rajadhyaksha, K. Darrell Berlin, Jonathan B. Gale, Edgar T. Miranda, Warren T. Ford, Erich C. Blossey, A. K. Verma, M. B. Hossain, and et al. pp 1474 - 1482; DOI: 10.1021/jm00391a033 |
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Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives Mark P. Wentland, Denis M. Bailey, E. John Alexander, Michael J. Castaldi, Richard A. Ferrari, Dean R. Haubrich, Daniel A. Luttinger, and Mark H. Perrone pp 1482 - 1489; DOI: 10.1021/jm00391a034 |
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X-ray crystal structure of the opioid ligand naltrexonazine Z. Urbanczyk-Lipkowska, A. W. Lipkowski, M. C. Etter, E. F. Hahn, G. W. Pasternak, and P. S. Portoghese pp 1489 - 1494; DOI: 10.1021/jm00391a035 |
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Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine M. Bobek, I. Kavai, and E. De Clercq pp 1494 - 1497; DOI: 10.1021/jm00391a036 |
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Synthesis and antifungal activity of a series of novel 1,2-disubstituted propenones Masaru Ogata, Hiroshi Matsumoto, Shiro Kida, Sumio Shimizu, Katsuya Tawara, and Yoshimi Kawamura pp 1497 - 1502; DOI: 10.1021/jm00391a037 |
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Progesterone derivatives that bind to the digitalis receptor: synthesis of 14.beta.-hydroxyprogesterone: a novel steroid with positive inotropic activity J. F. Templeton, V. P. Sashi Kumar, D. Cote, D. Bose, D. Elliott, R. S. Kim, and F. S. LaBella pp 1502 - 1505; DOI: 10.1021/jm00391a038 |
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Endoperoxides as potential antimalarial agents John A. Kepler, Abraham Philip, Y. W. Lee, H. A. Musallam, and F. Ivy Carroll pp 1505 - 1509; DOI: 10.1021/jm00391a039 |
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Synthesis and biological activities of arginine-vasopressin analogs with 4-hydroxyproline in position 7 Angeliki Buku, Irving L. Schwartz, Nocif Yamin, Herman R. Wyssbrod, and Diana Gazis pp 1509 - 1512; DOI: 10.1021/jm00391a040 |
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Structure activity studies on the C-terminal hexapeptide of substance P with modifications at the glutaminyl and methioninyl residues Constantine Poulos, George Stavropoulos, John R. Brown, and Christopher C. Jordan pp 1512 - 1515; DOI: 10.1021/jm00391a041 |
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Synthesis of 5-chloro-5,8-dideaza analogs of folic acid and aminopterin targeted for colon adenocarcinoma J. B. Hynes, A. Kumar, A. Tomazic, and W. L. Washtien pp 1515 - 1519; DOI: 10.1021/jm00391a042 |
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Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents Raymond A. Firestone, Judith M. Pisano, George M. Garrity, Robert A. Fromtling, and Sheldon B. Zimmerman pp 1519 - 1521; DOI: 10.1021/jm00391a043 |
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Preparation and antileukemic screening of some new 6'-deoxyhexopyranosyladenine nucleosides Leon M. Lerner, Bertrum Sheid, and Eric Gaetjens pp 1521 - 1525; DOI: 10.1021/jm00391a044 |
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[1-Desamino,7-lysine,8-arginine]vasotocin: attachment of reporter groups and affinity ligands through the lysine side chain Angeliki Buku, Patrick Eggena, Herman R. Wyssbrod, Irving L. Schwartz, Diana Gazis, Lisa I. Somoza, and John D. Glass pp 1526 - 1529; DOI: 10.1021/jm00391a045 |
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Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors Kenneth A. Jacobson, Andrzej W. Lipkowski, Terry W. Moody, William Padgett, Evelyn Pijl, Kenneth L. Kirk, and John W. Daly pp 1529 - 1532; DOI: 10.1021/jm00391a046 |
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Book Reviews pp 1533 - 1534; DOI: 10.1021/jm00391a600 |
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Indazoles as indole bioisosteres: synthesis and evaluation of the tropanyl ester and amide of indazole-3-carboxylate as antagonists at the serotonin 5HT3 receptor Pawel Fludzinski, Deborah A. Evrard, William E. Bloomquist, William B. Lacefield, William Pfeifer, Noel D. Jones, Jack B. Deeter, and Marlene L. Cohen pp 1535 - 1537; DOI: 10.1021/jm00392a001 |
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Synthesis and activity profiles of new dermorphin-(1-4) peptide analogs Mauro Marastoni, Severo Salvadori, Gianfranco Balboni, Pier Andrea Borea, Giuliano Marzola, and Roberto Tomatis pp 1538 - 1542; DOI: 10.1021/jm00392a002 |
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Nitrogen bridgehead compounds. 66. Bronchodilator nitrogen bridgehead compounds with a pyrimidinone moiety Istvan Hermecz, Lelle Vasvari-Debreczy, Agnes Horvath, Maria Balogh, Jozsef Kokosi, Christine DeVos, and Ludovic Rodriguez pp 1543 - 1549; DOI: 10.1021/jm00392a003 |
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Analogs of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione as selective inhibitors of aromatase: derivatives with variable 1-alkyl and 3-alkyl substituents Chui Sheung Leung, Martin G. Rowlands, Michael Jarman, Allan B. Foster, Leslie J. Griggs, and Derry E. V. Wilman pp 1550 - 1554; DOI: 10.1021/jm00392a004 |
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.alpha.2-Adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines Dennis J. Hlasta, Daniel Luttinger, Mark H. Perrone, Marla J. Silbernagel, Susan J. Ward, and Dean R. Haubrich pp 1555 - 1562; DOI: 10.1021/jm00392a005 |
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Carbostyril derivatives having potent .beta.-adrenergic agonist properties Jan Milecki, Stephen P. Baker, Kelly M. Standifer, Takashi Ishizu, Yasuhiro Chida, John W. Kusiak, and Josef Pitha pp 1563 - 1566; DOI: 10.1021/jm00392a006 |
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Resolved cis-10-hydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinoline: central serotonin stimulating properties Haakan Wikstroem, Bengt Andersson, Thomas Elebring, John Jacyno, Norman L. Allinger, Kjell Svensson, Arvid Carlsson, and Staffan Sundell pp 1567 - 1573; DOI: 10.1021/jm00392a007 |
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.gamma.-Aminobutyric acid esters. 3. Synthesis, brain uptake, and pharmacological properties of C-18 glyceryl lipid esters of GABA with varying degree of unsaturation James N. Jacob, Gary W. Hesse, and Victor E. Shashoua pp 1573 - 1576; DOI: 10.1021/jm00392a008 |
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Potential antitumor agents. 52. Carbamate analogs of amsacrine with in vivo activity against multidrug-resistant P388 leukemia Gordon W. Rewcastle, Bruce C. Baguley, Graham J. Atwell, and William A. Denny pp 1576 - 1581; DOI: 10.1021/jm00392a009 |
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17-Heteroaroyl esters of corticosteroids. 2. 11.beta.-Hydroxy series Elliot L. Shapiro, Margaret J. Gentles, Robert L. Tiberi, Thomas L. Popper, Joseph Berkenkopf, Barry Lutsky, and Arthur S. Watnick pp 1581 - 1588; DOI: 10.1021/jm00392a010 |
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Structure-activity relationships in an imidazole-based series of thromboxane synthase inhibitors Paul W. Manley, Nigel M. Allanson, Robert F. G. Booth, Philip E. Buckle, Edward J. Kuzniar, Nagin Lad, Steve M. F. Lai, David O. Lunt, and David P. Tuffin pp 1588 - 1595; DOI: 10.1021/jm00392a011 |
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Novel inhibitors of rat lens aldose reductase: N-[[(substituted amino)phenyl]sulfonyl]glycines Charles A. Mayfield and Jack DeRuiter pp 1595 - 1598; DOI: 10.1021/jm00392a012 |
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Isozyme-specific enzyme inhibitors. 14. 5'(R)-C-[(L-homocystein-S-yl)methyl]adenosine 5'-(.beta.,.gamma.-imidotriphosphate), a potent inhibitor of rat methionine adenosyltransferases Francis Kappler, Vivekananda M. Vrudhula, and Alexander Hampton pp 1599 - 1603; DOI: 10.1021/jm00392a013 |
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Phosphorus amino acid analogs as inhibitors of leucine aminopeptidase Peter P. Giannousis and Paul A. Bartlett pp 1603 - 1609; DOI: 10.1021/jm00392a014 |
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New inhibitors of human renin that contain novel Leu-Val replacements Jay R. Luly, Nwe Yi, Jeff Soderquist, Herman Stein, Jerome Cohen, Thomas J. Perun, and Jacob J. Plattner pp 1609 - 1616; DOI: 10.1021/jm00392a015 |
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Fluoro ketone containing peptides as inhibitors of human renin Karen Fearon, Andreas Spaltenstein, Paul B. Hopkins, and Michael H. Gelb pp 1617 - 1622; DOI: 10.1021/jm00392a016 |
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Pyridonecarboxylic acids as antibacterial agents. 9. Synthesis and antibacterial activity of 1-substituted 6-fluoro-1,4-dihydro-4-oxo-7-(4-pyridyl)-1,8-naphthyridine-3-carboxylic acids Yoshiro Nishimura and Junichi Matsumoto pp 1622 - 1626; DOI: 10.1021/jm00392a017 |
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Synthesis and biological properties of actinomycin D chromophoric analogs substituted at the 7-carbon with aziridine and aminopropoxy functions Raj K. Sehgal, Bijan Almassian, David P. Rosenbaum, Ruth Zadrozny, and Sisir K. Sengupta pp 1626 - 1631; DOI: 10.1021/jm00392a018 |
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Charged analogs of chlorpromazine as dopamine antagonists Marc W. Harrold, Yu An Chang, Raye Ann Wallace, Tahira Farooqui, Lane J. Wallace, Norman Uretsky, and Duane D. Miller pp 1631 - 1635; DOI: 10.1021/jm00392a019 |
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Synthesis and antiviral activity of 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]purines Michael R. Harnden, Richard L. Jarvest, Teresa H. Bacon, and Malcolm R. Boyd pp 1636 - 1642; DOI: 10.1021/jm00392a020 |
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1-Amino-substituted 4-methyl-5H-pyrido[3',4':4,5]pyrrolo[3,2-c]pyridines: a new class of antineoplastic agents Nguyen Chin Hung, Emile Bisagni, Odile Pepin, Alain Pierre, and Paul De Cointet pp 1642 - 1647; DOI: 10.1021/jm00392a021 |
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Aldosterone antagonists. 2. Synthesis and biological activities of 11,12-dehydropregnane derivatives Susumu Kamata, Takeaki Matsui, Nobuhiro Haga, Masuhisa Nakamura, Kunihiro Odaguchi, Takako Itoh, Toshikatsu Shimizu, Tetsuro Suzuki, Masahiro Ishibashi, and et al. pp 1647 - 1658; DOI: 10.1021/jm00392a022 |
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Analgesic dipeptide derivatives. 3. Synthesis and structure-activity relationships of o-nitrophenyl-modified analogs of the analgesic compound H-Lys-Trp(NPS)-OMe M. Teresa Garcia-Lopez, Rosario Gonzalez-Muniz, M. Teresa Molinero, Jose R. Naranjo, and J. Del Rio pp 1658 - 1663; DOI: 10.1021/jm00392a023 |
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5-Acyl-3-substituted benzofuran-2(3H)-ones as potential antiinflammatory agents Jiban K. Chakrabarti, Richard J. Eggleton, Peter T. Gallagher, Janette Harvey, Terence A. Hicks, E. Ann Kitchen, and Colin W. Smith pp 1663 - 1668; DOI: 10.1021/jm00392a024 |
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Synthesis and evaluation of melphalan-containing N,N-dialkylenkephalin analogs as irreversible antagonists of the .delta. opioid receptor Jane A. Lovett and Philip S. Portoghese pp 1668 - 1674; DOI: 10.1021/jm00392a025 |
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Carbonylacrylic derivatives as potential antimicrobial agents. Correlations between activity and reactivity toward cysteine Alma Dal Pozzo, Maurizio Acquasaliente, Giovanni Donzelli, Paolo De Maria, and M. Christina Nicoli pp 1674 - 1677; DOI: 10.1021/jm00392a026 |
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Toward a rationalization of the sensitizing potency of substituted p-benzoquinones. Reaction of nucleophiles with p-benzoquinones D. Cremer, B. M. Hausen, and H. W. Schmalle pp 1678 - 1681; DOI: 10.1021/jm00392a027 |
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Structural modification study of mitoxantrone (DHAQ). Chloro-substituted mono- and bis[(aminoalkyl)amino]anthraquinones Robert K.-Y. Zee-Cheng, Abraham E. Mathew, Pei-Ling Xu, Raymond V. Northcutt, and C. C. Cheng pp 1682 - 1686; DOI: 10.1021/jm00392a028 |
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Improved synthesis and antitumor activity of 1-deazaadenosine Gloria Cristalli, Palmarisa Franchetti, Mario Grifantini, Sauro Vittori, Teresa Bordoni, and Cristina Geroni pp 1686 - 1688; DOI: 10.1021/jm00392a029 |
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Anticoagulant peptides. Nature of the interaction of the C-terminal region of hirudin with a noncatalytic binding site on thrombin John L. Krstenansky, Thomas J. Owen, Mark T. Yates, and Simon J. T. Mao pp 1688 - 1691; DOI: 10.1021/jm00392a030 |
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Book Reviews pp 1691 - 1704; DOI: 10.1021/jm00392a600 |
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Inactivation of thymidylate synthase at an alternate high-affinity binding site Laman A. Al-Razzak, Douglas Schwepler, Charles J. Decedue, and Mathias P. Mertes pp 1705 - 1706; DOI: 10.1021/jm00393a001 |
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Diketopiperazines as a new class of platelet-activating factor inhibitors Norihiko Shimazaki, Ichiro Shima, Keiji Hemmi, and Masashi Hashimoto pp 1706 - 1709; DOI: 10.1021/jm00393a002 |
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N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity Alexander J. Bridges, Walter H. Moos, Deedee L. Szotek, Bharat K. Trivedi, James A. Bristol, Thomas G. Heffner, Robert F. Bruns, and David A. Downs pp 1709 - 1711; DOI: 10.1021/jm00393a003 |
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Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid: preparation and biological activity Townley P. Culbertson, John M. Domagala, Jeffery B. Nichols, Stephen Priebe, and Richard W. Skeean pp 1711 - 1715; DOI: 10.1021/jm00393a004 |
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Synthesis and biological properties of N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid dipeptides. A novel group of antimicrobial agents Ryszard Andruszkiewicz, Henryk Chmara, Slawomir Milewski, and Edward Borowski pp 1715 - 1719; DOI: 10.1021/jm00393a005 |
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Synthesis of angiotensin II antagonists with variations in position 5 Olga Nyeki, Katalin S. Szalay, Lajos Kisfaludy, Egon Karpati, Laszlo Szporny, Gabor B. Makara, and Bertalan Varga pp 1719 - 1724; DOI: 10.1021/jm00393a006 |
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Cardiotonic agents. 6. Synthesis and inotropic activity of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones: ring-contracted analogs of imazodan (CI-914) Ila Sircar, Glenn C. Morrison, Sandra E. Burke, Richard Skeean, and Ronald E. Weishaar pp 1724 - 1728; DOI: 10.1021/jm00393a007 |
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Renin inhibitors. Dipeptide analogs of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond Giorgio Bolis, Anthony K. L. Fung, Jonathan Greer, Hollis D. Kleinert, Patrick A. Marcotte, Thomas J. Perun, Jacob J. Plattner, and Herman H. Stein pp 1729 - 1737; DOI: 10.1021/jm00393a008 |
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1,3-Diarylpyrazolo[4,5-c]- and -[5,4-c]quinolin-4-ones. 4. Synthesis and specific inhibition of benzodiazepine receptor binding Giovanna Palazzino, Lucia Cecchi, Fabrizio Melani, Vittoria Colotta, Guido Filacchioni, Claudia Martini, and Antonio Lucacchini pp 1737 - 1742; DOI: 10.1021/jm00393a009 |
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Discovery and anticonvulsant activity of the potent metabolic inhibitor 4-amino-N-(2,6-dimethylphenyl)-3,5-dimethylbenzamide David W. Robertson, J. David Leander, Ron Lawson, E. E. Beedle, C. Randall Clark, Brian D. Potts, and C. John Parli pp 1742 - 1746; DOI: 10.1021/jm00393a010 |
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Synthesis of potential anticancer agents: imidazo[4,5-c]pyridines and imidazo[4,5-b]pyridines Carroll Temple, Jerry D. Rose, Robert N. Comber, and Gregory A. Rener pp 1746 - 1751; DOI: 10.1021/jm00393a011 |
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In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models Leonard Jurd, V. L. Narayanan, and Kenneth D. Paull pp 1752 - 1756; DOI: 10.1021/jm00393a012 |
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Synthesis and biological studies of iodinated (127/125I) derivatives of rhodamine 123 Berma M. Kinsey, Amin I. Kassis, Fahed Fayad, Warren W. Layne, and S. James Adelstein pp 1757 - 1761; DOI: 10.1021/jm00393a013 |
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Synthesis, conformational considerations, and estrogen receptor binding of diastereoisomers and enantiomers of 1-[4-[2-(dimethylamino)ethoxy]phenyl]-1,2-diphenylbutane (dihydrotamoxifen) Raymond McCague and Guy Leclercq pp 1761 - 1767; DOI: 10.1021/jm00393a014 |
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Synthesis and antineoplastic activity of 1a-formyl and 1a-thioformyl derivatives of mitomycin C and 2-methylaziridine Paul L. Fishbein and Harold Kohn pp 1767 - 1773; DOI: 10.1021/jm00393a015 |
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Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogs. Structure-activity correlations Mansukh C. Wani, Allan W. Nicholas, Govindarajan Manikumar, and Monroe E. Wall pp 1774 - 1779; DOI: 10.1021/jm00393a016 |
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Synthesis and structure-activity relationships of 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives having narcotic agonist and antagonist activity Kagayaki Natsuka, Hideo Nakamura, Yoshinori Nishikawa, Toshiyuki Negoro, Hitoshi Uno, and Haruki Nishimura pp 1779 - 1787; DOI: 10.1021/jm00393a017 |
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Studies on histamine H2 receptor antagonists. 2. Synthesis and pharmacological activities of N-sulfamoyl and N-sulfonyl amidine derivatives Isao Yanagisawa, Yasufumi Hirata, and Yoshio Ishii pp 1787 - 1793; DOI: 10.1021/jm00393a018 |
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2,4-Diamino-6,7-dimethoxyquinazolines. 3. 2-(4-heterocyclylpiperazin-1-yl) derivatives as .alpha.1-adrenoceptor antagonists and antihypertensive agents Simon F. Campbell and Rhona M. Plews pp 1794 - 1798; DOI: 10.1021/jm00393a019 |
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Effects of [(N-alkyl-1,3-dioxo-1H,3H-isoindolin-5-yl)oxy]alkanoic acids, [(N-alkyl-1-oxo-1H,3H-isoindolin-5-yl)oxy]butanoic acids, and related derivatives on chloride influx in primary astroglial cultures Steven D. Wyrick, Forrest T. Smith, W. Evans Kemp, and Anne A. Grippo pp 1798 - 1806; DOI: 10.1021/jm00393a020 |
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1,3-Dialkyl-4-(iminoarylmethyl)-1H-pyrazol-5-ols. A series of novel potential antipsychotic agents Lawrence D. Wise, Donald E. Butler, Horace A. DeWald, David M. Lustgarten, Ian C. Pattison, Dieter N. Schweiss, Linda L. Coughenour, David A. Downs, Thomas G. Heffner, and Thomas A. Pugsley pp 1807 - 1812; DOI: 10.1021/jm00393a021 |
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Thromboxane synthase inhibitors. Synthesis and pharmacological activity of (R)-, (S)-, and (.+-.)-2,2-dimethyl-6-[2-(1H-imidazol-1-yl)-1-[[(4-methoxyphenyl)methoxy]methyl]ethoxy]hexanoic acids Paul W. Manley, David P. Tuffin, Nigel M. Allanson, Philip E. Buckle, Nagin Lad, Steve M. F. Lai, David O. Lunt, Roderick A. Porter, and Patricia J. Wade pp 1812 - 1818; DOI: 10.1021/jm00393a022 |
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Antipsychotic activity of substituted .gamma.-carbolines Magid Abou-Gharbia, Usha R. Patel, Michael B. Webb, John A. Moyer, Terrance H. Andree, and Eric A. Muth pp 1818 - 1823; DOI: 10.1021/jm00393a023 |
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6-Methylergoline-8-carboxylic acid esters as serotonin antagonists: N1-substituent effects on 5HT2 receptor affinity Gifford Marzoni, William L. Garbrecht, Pawel Fludzinski, and Marlene L. Cohen pp 1823 - 1826; DOI: 10.1021/jm00393a024 |
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C1- and C3-methyl-substituted derivatives of 7-hydroxy-2-(di-n-propylamino)tetralin: activities at central dopamine receptors Anette M. Johansson, J. Lars G. Nilsson, Anders Karlen, Uli Hacksell, Domingo Sanchez, Kjell Svensson, Stephan Hjorth, Arvid Carlsson, Staffan Sundell, and Lennart Kenne pp 1827 - 1837; DOI: 10.1021/jm00393a025 |
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.alpha.,.alpha.-Difluoro-.beta.-aminodeoxystatine-containing renin-inhibitory peptides Suvit Thaisrivongs, Heinrich J. Schostarez, Donald T. Pals, and Steve R. Turner pp 1837 - 1842; DOI: 10.1021/jm00393a026 |
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Conformational analysis of antineoplastic antifolates: the crystal structure of trimetrexate and the aminopterine derivative 4-[N-[(2,4-diamino-6-pteridinyl)methyl]amino]benzoic acid Paul A. Sutton and Vivian Cody pp 1843 - 1848; DOI: 10.1021/jm00393a027 |
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Isothiourea derivatives of 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole with broad-spectrum anthelmintic activity Malcolm D. Brewer, Roderick J. J. Dorgan, Brian R. Manger, Patrick Mamalis, and Richard A. B. Webster pp 1848 - 1853; DOI: 10.1021/jm00393a028 |
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Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini Mark G. Bock, Robert M. DiPardo, Ben E. Evans, Kenneth E. Rittle, Joshua Boger, Martin Poe, Bruce I. LaMont, Robert J. Lynch, Edgar H. Ulm, and et al. pp 1853 - 1857; DOI: 10.1021/jm00393a029 |
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Total synthesis and biological evaluation of structural analogs of compactin and dihydromevinolin Clayton H. Heathcock, Cheri R. Hadley, Terry Rosen, Peter D. Theisen, and Scott J. Hecker pp 1858 - 1873; DOI: 10.1021/jm00393a030 |
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Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives Masaaki Asao, Hajime Iwamura, Miki Akamatsu, and Toshio Fujita pp 1873 - 1879; DOI: 10.1021/jm00393a031 |
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Synthesis of some [N-(2-haloalkyl)amino]tetralin derivatives as potential irreversible labels for bovine anterior pituitary D2 dopamine receptors A. W. Hall, R. J. K. Taylor, S. H. Simmonds, and P. G. Strange pp 1879 - 1887; DOI: 10.1021/jm00393a032 |
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Evaluation of isomeric 4-(chlorohydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines as dopamine D-1 antagonists Robert M. Riggs, David E. Nichols, Mark M. Foreman, and Lewis L. Truex pp 1887 - 1891; DOI: 10.1021/jm00393a033 |
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Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids Jeanette C. Roberts, Herbert T. Nagasawa, Richard T. Zera, Robert F. Fricke, and David J. W. Goon pp 1891 - 1896; DOI: 10.1021/jm00393a034 |
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Synthesis and antitumor activity of tropolone derivatives. 6. Structure-activity relationships of antitumor-active tropolone and 8-hydroxyquinoline derivatives Masatoshi Yamato, Kuniko Hashigaki, Yoshiko Yasumoto, Junko Sakai, Richard F. Luduena, Asok Banerjee, Shigeru Tsukagoshi, Tazuko Tashiro, and Takashi Tsuruo pp 1897 - 1900; DOI: 10.1021/jm00393a035 |
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Novel irreversible ligands specific for "peripheral" type benzodiazepine receptors: (.+-.)-, (+)- and (-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-N-(2-isothiocyanatoethyl)-3-isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one Amy Hauck Newman, Hartmut W. M. Lueddens, Phil Skolnick, and Kenner C. Rice pp 1901 - 1905; DOI: 10.1021/jm00393a036 |
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Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds M. A. Iorio, T. Paszkowska Reymer, and V. Frigeni pp 1906 - 1910; DOI: 10.1021/jm00393a037 |
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Effect of reductive alkylation of lysine in positions 6 and/or 8 on the histamine-releasing activity of luteinizing hormone-releasing hormone antagonists Simon J. Hocart, Mary V. Nekola, and David H. Coy pp 1910 - 1914; DOI: 10.1021/jm00393a038 |
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Effect of .beta.-alkyl substitution on D-1 dopamine agonist activity: absolute configuration of .beta.-methyldopamine Robert M. Riggs, Ann T. McKenzie, Stephen R. Byrn, David E. Nichols, Mark M. Foreman, and Lewis L. Truex pp 1914 - 1918; DOI: 10.1021/jm00393a039 |
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Streptonigrin and lavendamycin partial structures. Probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones Dale L. Boger, Masami Yasuda, Lester A. Mitscher, Steven D. Drake, Paul A. Kitos, and Sandra Collins Thompson pp 1918 - 1928; DOI: 10.1021/jm00393a040 |
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The dopaminergic moiety of the ergots. A controversial topic studied with molecular mechanics Hakaan Wikstroem, Jenn Huei Lii, and Norman L. Allinger pp 1928 - 1934; DOI: 10.1021/jm00393a041 |
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Molecular requirements of the recognition site of the cholinergic receptor. 24. Resolution, absolute configuration, and cholinergic enantioselectivity of (-)- and (+)-c-2-methyl-r-5-[(dimethylamino)methyl]-1,3-oxathiolane t-3-oxide methiodide and related sulfones E. Teodori, F. Gualtieri, P. Angeli, L. Brasili, and M. Giannella pp 1934 - 1938; DOI: 10.1021/jm00393a042 |
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Additions and Corrections - In Search of the Digitalis Replacement P.W. Erhardt pp 1938 - 1938; DOI: 10.1021/jm00393a600 |
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Book Reviews pp 1939 - 1940; DOI: 10.1021/jm00393a601 |
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Macrolides with gastrointestinal motor stimulating activity Satoshi Omura, Kazuo Tsuzuki, Toshiaki Sunazuka, Shogo Marui, Hajime Toyoda, Nobuhiro Inatomi, and Zen Itoh pp 1941 - 1943; DOI: 10.1021/jm00394a001 |
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Antimalarial activity of 2-(substituted amino)-4,6-bis(trichloromethyl)-1,3,5-triazines and N-(chlorophenyl)-N'-[4-(substituted amino)-6-(trichloromethyl)-1,3,5-triazin-2-yl]guanidines Leslie M. Werbel, Edward F. Elslager, Carolyn Hess, and Marland P. Hutt pp 1943 - 1948; DOI: 10.1021/jm00394a002 |
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Stereospecificity in allergic contact dermatitis to simple substituted methylene lactones derivatives Henri Mattes, Kaoru Hamada, and Claude Benezra pp 1948 - 1951; DOI: 10.1021/jm00394a003 |
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Synthesis and gastrointestinal pharmacology of the 4-fluoro analog of enisoprost Paul W. Collins, Steven W. Kramer, and Gary W. Gullikson pp 1952 - 1955; DOI: 10.1021/jm00394a004 |
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Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correlation with in vivo positive inotropic activity Ila Sircar, Ronald E. Weishaar, Dianne Kobylarz, Walter H. Moos, and James A. Bristol pp 1955 - 1962; DOI: 10.1021/jm00394a005 |
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Cardiotonic agents. 8. Selective inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III. Elaboration of a five-point model for positive inotropic activity Walter H. Moos, Christine C. Humblet, Ila Sircar, Christopher Rithner, Ronald E. Weishaar, James A. Bristol, and Andrew T. McPhail pp 1963 - 1972; DOI: 10.1021/jm00394a006 |
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Design, synthesis, and testing of potential antisickling agents. 10. 2,2-Dimethylchroman-6-ylalkanoic acids Majekodunmi O. Fatope and Donald J. Abraham pp 1973 - 1977; DOI: 10.1021/jm00394a007 |
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Renin inhibitors based on novel dipeptide analogs. Incorporation of the dehydrohydroxyethylene isostere at the scissile bond Dale J. Kempf, Ed De Lara, Herman H. Stein, Jerome Cohen, and Jacob J. Plattner pp 1978 - 1983; DOI: 10.1021/jm00394a008 |
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Angiotensin-converting enzyme inhibitors. Perhydro-1,4-thiazepin-5-one derivatives Hiroaki Yanagisawa, Sadao Ishihara, Akiko Ando, Takuro Kanazaki, Shuichi Miyamoto, Hiroyuki Koike, Yasuteru Iijima, Kiyoshi Oizumi, Yoichi Matsushita, and Tadashi Hata pp 1984 - 1991; DOI: 10.1021/jm00394a009 |
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Hybrid bivalent ligands with opiate and enkephalin pharmacophores Philip S. Portoghese, D. L. Larson, G. Ronsisvalle, P. W. Schiller, Nguyen Thi Mai Dung, C. Lemieux, and A. E. Takemori pp 1991 - 1994; DOI: 10.1021/jm00394a010 |
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Synthesis and antiinflammatory activities of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones H. Ikuta, H. Shirota, S. Kobayashi, Y. Yamagishi, K. Yamada, I. Yamatsu, and K. Katayama pp 1995 - 1998; DOI: 10.1021/jm00394a011 |
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2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 8. The 3,4,5-triethyl isostere of trimethoprim. A study of specificity Barbara Roth and Edward Aig pp 1998 - 2004; DOI: 10.1021/jm00394a012 |
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Antitumor agents. 89. Psychorubrin, a new cytotoxic naphthoquinone from Psychotria rubra and its structure-activity relationships Toshimitsu Hayashi, Forrest T. Smith, and Kuo Hsiung Lee pp 2005 - 2008; DOI: 10.1021/jm00394a013 |
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Carbamate ester derivatives as potential prodrugs of the presynaptic dopamine autoreceptor agonist (-)-3-(3-hydroxyphenyl)-N-propylpiperidine Seth Olov Thorberg, Stefan Berg, Jan Lundstroem, Bodil Pettersson, Agneta Wijkstroem, Domingo Sanchez, Per Lindberg, and J. Lars G. Nilsson pp 2008 - 2012; DOI: 10.1021/jm00394a014 |
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Facile synthesis of 2-[(3-aminopropyl)thio]adenosine 5'-diphosphate: a key intermediate for the synthesis of molecular probes of adenosine 5'-diphosphate function John R. Jefferson, John B. Hunt, and G. A. Jamieson pp 2013 - 2016; DOI: 10.1021/jm00394a015 |
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Nitrogen-bridged conformationally constrained etorphine analogs. Synthesis and biological evaluation Peter J. Maurer and Henry Rapoport pp 2016 - 2026; DOI: 10.1021/jm00394a016 |
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Synthesis and antiviral activity of carbocyclic analogs of xylofuranosides of 2-amino-6-substituted-purines and 2-amino-6-substituted-8-azapurines Robert Vince, Rajesh H. Turakhia, William M. Shannon, and Gussie Arnett pp 2026 - 2030; DOI: 10.1021/jm00394a017 |
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Antiulcer agents. 2. Gastric antisecretory, cytoprotective, and metabolic properties of substituted imidazo[1,2-a]pyridines and analogs James J. Kaminski, James M. Hilbert, B. N. Pramanik, Daniel M. Solomon, David J. Conn, Razia K. Rizvi, Arthur J. Elliott, Henry Guzik, Raymond G. Lovey, and et al. pp 2031 - 2046; DOI: 10.1021/jm00394a018 |
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Antiulcer agents. 3. Structure-activity-toxicity relationships of substituted imidazo[1,2-a]pyridines and a related imidazo[1,2-a]pyrazine James J. Kaminski, D. G. Perkins, J. D. Frantz, Daniel M. Solomon, Arthur J. Elliott, P. J. S. Chiu, and James F. Long pp 2047 - 2051; DOI: 10.1021/jm00394a019 |
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Metabolic synthesis of arylacetic acid antiinflammatory drugs from arylhexenoic acids. 2. Indomethacin J. W. Gillard and P. Belanger pp 2051 - 2058; DOI: 10.1021/jm00394a020 |
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Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors Alan R. Katritzky, Kenneth C. Caster, Thomas H. Maren, Curtis W. Conroy, and Amir Bar-Ilan pp 2058 - 2062; DOI: 10.1021/jm00394a021 |
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Design and synthesis of phosphonate inhibitors of glutamine synthetase G. King Farrington, Alok Kumar, and Frederick C. Wedler pp 2062 - 2067; DOI: 10.1021/jm00394a022 |
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A 500-MHz proton nuclear magnetic resonance study of .mu. opioid peptides in a simulated receptor environment M. A. Castiglione-Morelli, F. Lelj, A. Pastore, S. Salvadori, T. Tancredi, R. Tomatis, E. Trivellone, and P. A. Temussi pp 2067 - 2073; DOI: 10.1021/jm00394a023 |
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Modulation of the antitumor activity by methyl substitutions in the series of 7H-pyridocarbazole monomers and dimers P. Leon, C. Garbay-Jaureguiberry, M. C. Barsi, J. B. Le Pecq, and Bernard P. Roques pp 2074 - 2080; DOI: 10.1021/jm00394a024 |
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Potential antitumor agents. 53. Synthesis, DNA binding properties, and biological activity of perimidines designed as minimal DNA-intercalating agents John M. Herbert, Paul D. Woodgate, and William A. Denny pp 2081 - 2086; DOI: 10.1021/jm00394a025 |
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Phenylephrine derivatives as leukotriene D4 antagonists John H. Musser, Dennis M. Kubrak, Reinhold H. W. Bender, Anthony F. Kreft, Susan T. Nielsen, Allan M. Lefer, Joseph Chang, Alan J. Lewis, and James M. Hand pp 2087 - 2093; DOI: 10.1021/jm00394a026 |
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Structure-activity relationships of cyclic opioid peptide analogs containing a phenylalanine residue in the 3-position Peter W. Schiller, Louise A. Maziak, Brian C. Wilkes, Carole Lemieux, and Nguyen Thi Mai Dung pp 2094 - 2099; DOI: 10.1021/jm00394a027 |
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2-Phenylpyrroles as conformationally restricted benzamide analogs. A new class of potential antipsychotics. 1 Ineke Van Wijngaarden, Chris G. Kruse, Roelof Van Hes, Jan A. M. Van der Heyden, and Martin T. M. Tulp pp 2099 - 2104; DOI: 10.1021/jm00394a028 |
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(+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist Lars Erik Arvidsson, Anette M. Johansson, Uli Hacksell, J. Lars G. Nilsson, K. Svewnsson, Stephan Hjorth, Tor Magnusson, Arvid Carlsson, Bengt Andersson, and Hakan Wikstroem pp 2105 - 2109; DOI: 10.1021/jm00394a029 |
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Vinylogous carbinolamine tumor inhibitors. 21. Synthesis, chemical reactivity, and antileukemic activity of 5-substituted 6,7-bis(hydroxymethyl)pyrrolo[1,2-c]thiazole biscarbamates and the corresponding sulfoxides and sulfones Wayne K. Anderson and Robert H. Mach pp 2109 - 2115; DOI: 10.1021/jm00394a030 |
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Congener derivatives and conjugates of histamine: synthesis and tissue and receptor selectivity of the derivatives M. M. Khan, K. L. Melmon, D. Marr-Leisy, M. S. Verlander, M. Egli, S. Lok, and M. Goodman pp 2115 - 2120; DOI: 10.1021/jm00394a031 |
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In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase James B. Summers, Bruce P. Gunn, Hormoz Mazdiyasni, Andrew M. Goetze, Patrick R. Young, Jennifer B. Bouska, Richard D. Dyer, Dee W. Brooks, and George W. Carter pp 2121 - 2126; DOI: 10.1021/jm00394a032 |
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.alpha.-Melanotropin: the minimal active sequence in the frog skin bioassay Victor J. Hruby, Brian C. Wilkes, Mac E. Hadley, Fahad Al-Obeidi, Tomi K. Sawyer, Douglas J. Staples, Ann E. DeVaux, Orin Dym, Ana Maria de L. Castrucci, and et al. pp 2126 - 2130; DOI: 10.1021/jm00394a033 |
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Synthesis and anti-HIV activity of various 2'- and 3'-substituted 2',3'-dideoxyadenosines: a structure-activity analysis P. Herdewijn, R. Pauwels, M. Baba, J. Balzarini, and E. De Clercq pp 2131 - 2137; DOI: 10.1021/jm00394a034 |
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Optimization and in vivo evaluations of a series of small, potent, and specific renin inhibitors containing a novel Leu-Val replacement Joseph F. Dellaria, Robert G. Maki, Barbara A. Bopp, Jerome Cohen, Hollis D. Kleinert, Jay R. Luly, Ilmar Merits, Jacob J. Plattner, and Herman H. Stein pp 2137 - 2144; DOI: 10.1021/jm00394a035 |
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3-Pyrroline N-oxide bis(carbamate) tumor inhibitors as analogs of indicine N-oxide Wayne K. Anderson and Arnold S. Milowsky pp 2144 - 2147; DOI: 10.1021/jm00394a036 |
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Antimalarial activity of new water-soluble dihydroartemisinin derivatives Ai Jeng Lin, Daniel L. Klayman, and Wilbur K. Milhous pp 2147 - 2150; DOI: 10.1021/jm00394a037 |
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Antimalarial drugs. 63. Synthesis and antimalarial and antitumor effects of 2-amino-4-(hydrazino and hydroxyamino)-6-[(aryl)thio]quinazolines Leslie M. Werbel and Margaret J. Degnan pp 2151 - 2154; DOI: 10.1021/jm00394a038 |
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Acetylenic nucleosides. 4. 1-(.beta.-D-Arabinofuranosyl)-5-ethynylcytosine. Improved synthesis and evaluation of biochemical and antiviral properties Miroslav Bobek, I. Kavai, R. A. Sharma, S. Grill, G. Dutschman, and Y. C. Cheng pp 2154 - 2157; DOI: 10.1021/jm00394a039 |
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1,2-Bis(sulfonyl)hydrazines. 3. Effects of structural modification on antineoplastic activity Krishnamurthy Shyam, Robert T. Hrubiec, Ryosuke Furubayashi, Lucille A. Cosby, and Alan C. Sartorelli pp 2157 - 2161; DOI: 10.1021/jm00394a040 |
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Book Reviews pp 2162 - 2162; DOI: 10.1021/jm00394a600 |
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Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones Toshio Uno, Masanori Takamatsu, Yoshimasa Inoue, Yoshihiro Kawahata, Koji Iuchi, and Goro Tsukamoto pp 2163 - 2169; DOI: 10.1021/jm00395a001 |
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N-Substituted 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines and 3-phenylpiperidines: effects on central dopamine and .sigma. receptors Haakan Wikstroem, Bengt Andersson, Thomas Elebring, Kjell Svensson, Arvid Carlsson, and Brian Largent pp 2169 - 2174; DOI: 10.1021/jm00395a002 |
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Quantitative structure-activity relationships and eudismic analyses of the presynaptic dopaminergic activity and dopamine D2 and .sigma. receptor affinities of 3-(3-hydroxyphenyl)piperidines and octahydrobenzo[f]quinolines Han Van de Waterbeemd, Nabil El Tayar, Bernard Testa, Haakan Wikstroem, and Brian Largent pp 2175 - 2181; DOI: 10.1021/jm00395a003 |
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Antitumor activity of bis(diphenylphosphino)alkanes, their gold(I) coordination complexes, and related compounds Christopher K. Mirabelli, David T. Hill, Leo F. Faucette, Francis L. McCabe, Gerald R. Girard, Deborah B. Bryan, Blaine M. Sutton, Joan O. Leary Barus, Stanley T. Crooke, and Randall K. Johnson pp 2181 - 2190; DOI: 10.1021/jm00395a004 |
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Conformationally defined adrenergic agents. 10. Binding orientation of amphetamine and norfenfluramine analogs in the benzonorbornene and benzobicyclo[3.2.1]octane ring systems at the active site of phenylethanolamine N-methyltransferase (PNMT) Gary L. Grunewald, Kimberly M. Markovich, and Daniel J. Sall pp 2191 - 2208; DOI: 10.1021/jm00395a005 |
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Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4-tetrahydroisoquinolines. Further studies on the hydrophilic pocket of the aromatic ring binding region of the active site Daniel J. Sall and Gary L. Grunewald pp 2208 - 2216; DOI: 10.1021/jm00395a006 |
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Novel 1H-benzimidazol-4-ols with potent 5-lipoxygenase inhibitory activity Derek R. Buckle, Keith A. Foster, John F. Taylor, John M. Tedder, Veronica E. Thody, Richard A. B. Webster, Jose Bermudez, Roger E. Markwell, and Stephen A. Smith pp 2216 - 2221; DOI: 10.1021/jm00395a007 |
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Aryl diazo compounds and diazonium salts as potential irreversible probes of the GABA receptor Marie Jeanne Bouchet, Alvaro Rendon, Camille G. Wermuth, Maurice Goeldner, and Christian Hirth pp 2222 - 2227; DOI: 10.1021/jm00395a008 |
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N-Substituted oxopyrimidines and nucleosides: structure-activity relationship for hypnotic activity as CNS depressant Ikuo Yamamoto, Toshiyuki Kimura, Yuji Tateoka, Kazuhito Watanabe, and Ing Kang Ho pp 2227 - 2231; DOI: 10.1021/jm00395a009 |
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New antifilarial agents. 1. Epoxy sulfonamides and ethynesulfonamides Marie Josephe Brienne, Daniel Varech, Martine Leclercq, Jean Jacques, Nathalie Radembino, Christine Dessalles, Georges Mahuzier, Chantal Gueyouche, Christian Bories, and et al. pp 2232 - 2239; DOI: 10.1021/jm00395a010 |
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Synthesis of new antiinflammatory steroidal 20-carboxamides: (20R)- and (20S)-21-(N-substituted amino)-11.beta.,17,20-trihydroxy-3,21-dioxo-1,4-pregnadiene Hyun P. Kim, John Bird, Ann S. Heiman, George F. Hudson, Irach B. Taraporewala, and Henry J. Lee pp 2239 - 2244; DOI: 10.1021/jm00395a011 |
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C-Terminal deletions in antagonistic analogs of vasopressin that improve their specificities for antidiuretic (V2) and vasopressor (V1) receptors Maurice Manning, Aleksandra Misicka, Aleksandra Olma, Wieslaw A. Klis, Krzysztof Bankowski, Eleonora Nawrocka, Marian Kruszynski, Aleksander Kolodziejczyk, Ling Ling Cheng, and et al. pp 2245 - 2252; DOI: 10.1021/jm00395a012 |
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Synthesis and 5-hydroxytryptamine antagonist activity of 2-[[2-(dimethylamino)ethyl]thio]-3-phenylquinoline and its analogs Thomas P. Blackburn, Barry Cox, Allen J. Guildford, David J. Le Count, Derek N. Middlemiss, Robert J. Pearce, and Craig W. Thornber pp 2252 - 2259; DOI: 10.1021/jm00395a013 |
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Synthesis and cardiac electrophysiological activity of 2- and 3-[(substituted phenyl)alkyl]quinuclidines. Structure-activity relationships Thomas K. Morgan, Randall Lis, Anthony J. Marisca, Thomas M. Argentieri, Mark E. Sullivan, and Samuel S. Wong pp 2259 - 2269; DOI: 10.1021/jm00395a014 |
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2-Oxo-1,8-naphthyridine-3-carboxylic acid derivatives with potent gastric antisecretory properties Arthur A. Santilli, Anthony C. Scotese, Raymond F. Bauer, and Stanley C. Bell pp 2270 - 2277; DOI: 10.1021/jm00395a015 |
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Thromboxane synthetase inhibitors and antihypertensive agents. 4. N-[(1H-imidazol-1-yl)alkyl] derivatives of quinazoline-2,4(1H,3H)-diones, quinazolin-4(3H)-ones, and 1,2,3-benzotriazin-4(3H)-ones William B. Wright, Andrew S. Tomcufcik, Peter S. Chan, Joseph W. Marsico, and Jeffery B. Press pp 2277 - 2283; DOI: 10.1021/jm00395a016 |
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Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin) Lester A. Mitscher, Padam N. Sharma, Daniel T. W. Chu, Linus L. Shen, and Andre G. Pernet pp 2283 - 2286; DOI: 10.1021/jm00395a017 |
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Renin inhibitors. Free-Wilson and correlation analysis of the inhibitory potency of a series of pepstatin analogs on plasma renin Dino Nisato, Jean Wagnon, Georges Callet, Daniel Mettefeu, Jean Louis Assens, Claude Plouzane, Bernard Tonnerre, Vladimir Pliska, and Jean Luc Fauchere pp 2287 - 2291; DOI: 10.1021/jm00395a018 |
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Potent vasopressin antagonist modified at the carboxy-terminal tripeptide tail Fadia El-Fehail Ali, Hsin Lan Chang, William F. Huffman, Grace Heckman, Lewis B. Kinter, Edwin F. Weidley, Richard Edwards, Dulcie Schmidt, Daryl Ashton-Shue, and Frans L. Stassen pp 2291 - 2294; DOI: 10.1021/jm00395a019 |
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[(6,7-Dichlorobenzo[b]thien-5-yl)oxy]acetic acids and 1,1-dioxides. 1. A structurally novel class of diuretics with hypotensive activity Helen H. Ong, Steven R. Caldwell, James A. Profitt, John J. Tegeler, Marc N. Agnew, Jeffrey C. Wilker, Rudyard J. Ress, and Jan M. Kitzen pp 2295 - 2303; DOI: 10.1021/jm00395a020 |
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Synthesis and antiarrhythmic activity of novel 3-alkyl-1-[.omega.-[4-[(alkylsulfonyl)amino]phenyl]-.omega.-hydroxyalkyl]-1H-imidazolium salts and related compounds. 2 Randall Lis, David D. Davey, Thomas K. Morgan, William C. Lumma, Ronald A. Wohl, Vijay K. Jain, Chung Nan Wan, Thomas M. Argentieri, Mark E. Sullivan, and Elinor H. Cantor pp 2303 - 2309; DOI: 10.1021/jm00395a021 |
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Design and synthesis of peptide derivatives of a 3-deoxy-D-manno-2-octulosonic acid (KDO) analog as novel antibacterial agents acting upon lipopolysaccharide biosynthesis Alf Claesson, Anita M. Jansson, Brian G. Pring, Stephen M. Hammond, and Bertil Ekstroem pp 2309 - 2313; DOI: 10.1021/jm00395a022 |
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Nucleosides. 146. 1-Methyl-5-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)uracil, the C-nucleoside isostere of the potent antiviral agent, 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)thymine (FMAU). Studies directed toward the synthesis of 2'-deoxy-2'-substituted arabino nucleosides. 6 Krzysztof W. Pankiewicz, Barbara Nawrot, Hakan Gadler, Pichard W. Price, and Kyoichi A. Watanabe pp 2314 - 2316; DOI: 10.1021/jm00395a023 |
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Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3',4'-f].DELTA.6,8-tetrahydroindolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin Mansukh C. Wani, Allan W. Nicholas, and Monroe E. Wall pp 2317 - 2319; DOI: 10.1021/jm00395a024 |
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Additions and Corrections-Synthesis and Antiviral Activity of Various 3'-Azido, 3'-Amino, 2',3'-Unsaturated, and 2',3'-Dideoxy Analogues of Pyrimidine Deoxyribonucleosides against Retroviruses Tai-Shun Lin, Ming S. Chen, Colin McLaren, You-Song Gao, Ismail Ghazzouli, and William H. Prusoff pp 2319 - 2319; DOI: 10.1021/jm00395a600 |
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Book Reviews pp 2320 - 2322; DOI: 10.1021/jm00395a601 |